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- W69243985 abstract "This chapter reviews clinicopathological studies that illuminate the manner in which cerebrovascular disease (CVD) and Alzheimer’s disease (AD) pathology may interact to produce dementia. It does not consider the role of congophilic angiopathy, which is examined in Chapter 19. Central to the view put forward here is the idea that altered functional performance in cognition with aging depends on brain reserve capacity falling below a certain threshold or pathology exceeding a tolerance threshold (or both): brain reserve capacity is reduced with ageing while the burden of AD and vascular pathology rises; at some point, the reserve capacity is exhausted and combinations of AD pathology and CVD then cause dementia." @default.
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- W69243985 date "2005-01-01" @default.
- W69243985 modified "2023-09-25" @default.
- W69243985 title "Cerebrovascular Disease and the Expression of Alzheimer’s Disease" @default.
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- W69243985 doi "https://doi.org/10.1385/1-59259-824-2:275" @default.
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