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- W69276452 abstract "In the introduction, we asked how MHC molecules on the surfaces of APC make contact with antigen-specific receptors on the surfaces of T cells. We have reviewed two models in which antigen-specific contacts occur with primary leukocyte populations in vitro. One system involves resting T cells; the other sensitized T lymphoblasts. At the onset of a primary immune response, dendritic cells seem critical for binding and activating both CD4+ and CD8+ subsets. Given the current evidence, we suggest that dendritic cells literally find the right T cell clone, and not vice versa, and that dendritic cells do so by first binding and surveying T cells by an antigen-independent mechanism. In the efferent limb of immunity, other types of APC including B cells and macrophages bind and stimulate freshly sensitized T lymphoblasts. Freshly isolated epidermal Langerhans cells do not cluster T cells by an antigen-independent mechanism but acquire this capacity during epidermal suspension culture. Under the control of GM-CSF, the Langerhans cell becomes a powerful accessory cell for the primary or sensitization limb of T-dependent immune responses like the MLR and primary antibody response. Isolated lymphoid dendritic cells have many features in common with interdigitating cells in lymphoid T areas, and may be related to some of the irregularly-shaped Ia+ cells in certain epithelia and interstitial regions. Contact with dendritic cells may be important in both central and peripheral pathways of T cell sensitization in situ." @default.
- W69276452 created "2016-06-24" @default.
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- W69276452 date "1988-01-01" @default.
- W69276452 modified "2023-09-26" @default.
- W69276452 title "The Binding of Antigen Presenting Cells to T Lymphocytes" @default.
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- W69276452 doi "https://doi.org/10.1007/978-1-4684-5535-9_4" @default.
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