Matches in SemOpenAlex for { <https://semopenalex.org/work/W69307974> ?p ?o ?g. }
- W69307974 abstract "The Mediator complex is an essential multiprotein coregulator of RNA polymerase II (pol II)dependent transcription in fungi and metazoans. Mediator interacts directly with both pol II and sequence-specific transcriptional regulators and thus acting as a bridge between the two. We have performed a comparative biochemical and functional characterisation the Mediator in the two ascomycete yeasts S. cerevisiae and S. pombe to address to what degree subunit architecture and specific regulatory functions have been conserved between these two species. In Paper I we identified the Med31 protein as a stable subunit of Mediator in S. cerevisiae and S. pombe. We defined a highly conserved central motif in the Med31 protein that appeared to be required but not sufficient for the association of Med31 with the rest of the Mediator complex. In Paper II we investigated the structural basis for the global shutdown of pol IIdependent transcription in the S. cerevisiae MED17 temperature sensitive allele srb4-138. We found that the srb4-138 allele disrupts the interaction between the head and middle domains both in vitro and in vivo. This suggested that the global shutdown of transcription in srb4-138 cells at the non-permissive temperature is caused by destabilisation of the core Mediator" @default.
- W69307974 created "2016-06-24" @default.
- W69307974 creator A5035772890 @default.
- W69307974 date "2007-02-16" @default.
- W69307974 modified "2023-09-24" @default.
- W69307974 title "CONSERVED STRUCTURE-FUNCTION RELATIONSHIPS IN THE MEDIATOR COMPLEX" @default.
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