Matches in SemOpenAlex for { <https://semopenalex.org/work/W69419588> ?p ?o ?g. }
- W69419588 endingPage "105" @default.
- W69419588 startingPage "85" @default.
- W69419588 abstract "ConclusionBoth C and Aδ nociceptive neurones express multiple subtypes of Na+ channel. In particular, TTX-resistant Na+ channels appear to play an important role in determining the behaviour of these neurones. Present evidence suggests that initiation of nerve impulses in the sensory nerve terminals of nociceptors is dependent on the activation of TTX-resistant channels. Furthermore, the voltage dependence and kinetics of these Na+ channels may, at least in part, explain why these receptors have high sensory thresholds. In accord with this idea, a range of hyperalgesic agents released in inflamed tissue have been demonstrated to modify the behaviour of Na+ current attributed to Nav1.8 channels in a manner that will lower the voltage threshold for initiating action potentials. However, this action of hyperalgesic agents is likely to be only one of a range of mechanisms that contribute to inflammatory pain. For example, increased expression of both TTX-sensitive and TTX-resistant Na+ channels may also contribute to lowering the voltage threshold and changing the firing characteristics of nociceptive nerve endings.Based on current evidence, selective blockade of Na+ channel subtypes, in particular Nav1.8 and/or Nav1.9, may prove useful in controlling painful signals arising from damaged tissue without interfering with other neural functions. Blockade of these channel subtypes may also prove useful in inhibiting neurogenic inflammation of local origin." @default.
- W69419588 created "2016-06-24" @default.
- W69419588 creator A5041943774 @default.
- W69419588 date "2005-12-26" @default.
- W69419588 modified "2023-10-17" @default.
- W69419588 title "Sodium channels and nociceptive nerve endings" @default.
- W69419588 cites W1495409864 @default.
- W69419588 cites W1509844096 @default.
- W69419588 cites W1549160512 @default.
- W69419588 cites W1590770581 @default.
- W69419588 cites W1617355594 @default.
- W69419588 cites W163561699 @default.
- W69419588 cites W1828385583 @default.
- W69419588 cites W1831695691 @default.
- W69419588 cites W1965779217 @default.
- W69419588 cites W1968844130 @default.
- W69419588 cites W1975051009 @default.
- W69419588 cites W1978939719 @default.
- W69419588 cites W1985172868 @default.
- W69419588 cites W1985689777 @default.
- W69419588 cites W1986715632 @default.
- W69419588 cites W1992524499 @default.
- W69419588 cites W1992818845 @default.
- W69419588 cites W1995100344 @default.
- W69419588 cites W1997220636 @default.
- W69419588 cites W2000702493 @default.
- W69419588 cites W2004107882 @default.
- W69419588 cites W2007944782 @default.
- W69419588 cites W2008465842 @default.
- W69419588 cites W2013173477 @default.
- W69419588 cites W2013947622 @default.
- W69419588 cites W2017201947 @default.
- W69419588 cites W2017299181 @default.
- W69419588 cites W2018166097 @default.
- W69419588 cites W2020841267 @default.
- W69419588 cites W2020926989 @default.
- W69419588 cites W2022050392 @default.
- W69419588 cites W2026625183 @default.
- W69419588 cites W2027270039 @default.
- W69419588 cites W2031102231 @default.
- W69419588 cites W2033533301 @default.
- W69419588 cites W2034260493 @default.
- W69419588 cites W2035131069 @default.
- W69419588 cites W2035451747 @default.
- W69419588 cites W2041857602 @default.
- W69419588 cites W2045459703 @default.
- W69419588 cites W2051109362 @default.
- W69419588 cites W2057169654 @default.
- W69419588 cites W2058327557 @default.
- W69419588 cites W2061356511 @default.
- W69419588 cites W2062827290 @default.
- W69419588 cites W2063756211 @default.
- W69419588 cites W2068707948 @default.
- W69419588 cites W2079576606 @default.
- W69419588 cites W2088944306 @default.
- W69419588 cites W2089952714 @default.
- W69419588 cites W2091746433 @default.
- W69419588 cites W2097482307 @default.
- W69419588 cites W2097697084 @default.
- W69419588 cites W2105493663 @default.
- W69419588 cites W2108718363 @default.
- W69419588 cites W2112373417 @default.
- W69419588 cites W2117963590 @default.
- W69419588 cites W2127934652 @default.
- W69419588 cites W2134321467 @default.
- W69419588 cites W2140695849 @default.
- W69419588 cites W2140752409 @default.
- W69419588 cites W2147268397 @default.
- W69419588 cites W2148281583 @default.
- W69419588 cites W2150340080 @default.
- W69419588 cites W2162723169 @default.
- W69419588 cites W2170266506 @default.
- W69419588 cites W2238188566 @default.
- W69419588 cites W2339447116 @default.
- W69419588 cites W2411133343 @default.
- W69419588 cites W2411384047 @default.
- W69419588 cites W40340874 @default.
- W69419588 cites W4243348120 @default.
- W69419588 doi "https://doi.org/10.1007/3-7643-7411-x_5" @default.
- W69419588 hasPublicationYear "2005" @default.
- W69419588 type Work @default.
- W69419588 sameAs 69419588 @default.
- W69419588 citedByCount "0" @default.
- W69419588 crossrefType "book-chapter" @default.
- W69419588 hasAuthorship W69419588A5041943774 @default.
- W69419588 hasConcept C105702510 @default.
- W69419588 hasConcept C136357698 @default.
- W69419588 hasConcept C15490471 @default.
- W69419588 hasConcept C169760540 @default.
- W69419588 hasConcept C170493617 @default.
- W69419588 hasConcept C172659308 @default.
- W69419588 hasConcept C178790620 @default.
- W69419588 hasConcept C185592680 @default.
- W69419588 hasConcept C2778468042 @default.
- W69419588 hasConcept C50952357 @default.
- W69419588 hasConcept C537181965 @default.
- W69419588 hasConcept C55493867 @default.
- W69419588 hasConcept C71924100 @default.