FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W69440101> ?p ?o ?g. }

• W69440101 abstract "Abstract We investigated the effect of interleukin-6 (IL-6) on murine megakaryocytopoiesis in a serum-free culture system. The addition of IL- 6 to a culture containing interleukin-3 (IL-3) resulted in a significant increase in the number of megakaryocyte colonies by bone marrow cells of normal mice. The megakaryocytic progenitors that survive exposure to 5-fluorouracil (5-FU) exhibited a more significant response to IL-6 and IL-3. Polyclonal anti-IL-6 antibody neutralized the stimulatory effect of IL-6 on megakaryocyte colony growth supported by IL-3. Delayed addition experiments and replating experiments of blast cell colonies showed that megakaryocytic progenitors are supported by IL-3 in the early stage of the development but require IL- 6 for their subsequent proliferation and differentiation. In addition, IL-6 increased the size of megakaryocytes in granulocyte-macrophage- megakaryocyte colonies. The combination of granulocyte colony- stimulating factor or granulocyte-macrophage colony stimulating factor with IL-3 resulted in an increase in the granulocyte-macrophage colony growth of bone marrow cells of 5-FU-treated mice or normal mice, respectively, but had little effect on the enhancement of pure and mixed megakaryocyte colony growth. These results suggest that IL-6 plays an important role in murine megakaryocytopoiesis." @default.
• W69440101 created "2016-06-24" @default.
• W69440101 creator A5007950935 @default.
• W69440101 creator A5013169655 @default.
• W69440101 creator A5030021970 @default.
• W69440101 creator A5030027073 @default.
• W69440101 creator A5033403685 @default.
• W69440101 creator A5035895631 @default.
• W69440101 creator A5046834763 @default.
• W69440101 creator A5077384482 @default.
• W69440101 creator A5078215577 @default.
• W69440101 creator A5085412841 @default.
• W69440101 date "1990-06-15" @default.
• W69440101 modified "2023-09-27" @default.
• W69440101 title "Interleukin-6 enhances murine megakaryocytopoiesis in serum-free culture" @default.
• W69440101 cites W1490062267 @default.
• W69440101 cites W1520846637 @default.
• W69440101 cites W1814728082 @default.
• W69440101 cites W182367328 @default.
• W69440101 cites W1967563165 @default.
• W69440101 cites W1989271276 @default.
• W69440101 cites W1990786859 @default.
• W69440101 cites W2002076761 @default.
• W69440101 cites W2004650098 @default.
• W69440101 cites W2018552733 @default.
• W69440101 cites W2024739367 @default.
• W69440101 cites W2033093905 @default.
• W69440101 cites W2049652135 @default.
• W69440101 cites W2054663403 @default.
• W69440101 cites W2085264697 @default.
• W69440101 cites W2086448999 @default.
• W69440101 cites W2405881143 @default.
• W69440101 cites W2409811290 @default.
• W69440101 cites W2418064775 @default.
• W69440101 cites W2422717905 @default.
• W69440101 cites W2441757074 @default.
• W69440101 doi "https://doi.org/10.1182/blood.v75.12.2286.2286" @default.
• W69440101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2350576" @default.
• W69440101 hasPublicationYear "1990" @default.
• W69440101 type Work @default.
• W69440101 sameAs 69440101 @default.
• W69440101 citedByCount "43" @default.
• W69440101 countsByYear W694401012013 @default.
• W69440101 crossrefType "journal-article" @default.
• W69440101 hasAuthorship W69440101A5007950935 @default.
• W69440101 hasAuthorship W69440101A5013169655 @default.
• W69440101 hasAuthorship W69440101A5030021970 @default.
• W69440101 hasAuthorship W69440101A5030027073 @default.
• W69440101 hasAuthorship W69440101A5033403685 @default.
• W69440101 hasAuthorship W69440101A5035895631 @default.
• W69440101 hasAuthorship W69440101A5046834763 @default.
• W69440101 hasAuthorship W69440101A5077384482 @default.
• W69440101 hasAuthorship W69440101A5078215577 @default.
• W69440101 hasAuthorship W69440101A5085412841 @default.
• W69440101 hasBestOaLocation W694401011 @default.
• W69440101 hasConcept C109159458 @default.
• W69440101 hasConcept C131665280 @default.
• W69440101 hasConcept C153911025 @default.
• W69440101 hasConcept C201750760 @default.
• W69440101 hasConcept C203014093 @default.
• W69440101 hasConcept C2776090121 @default.
• W69440101 hasConcept C2777478134 @default.
• W69440101 hasConcept C2777863708 @default.
• W69440101 hasConcept C2777918643 @default.
• W69440101 hasConcept C2777983669 @default.
• W69440101 hasConcept C2778690821 @default.
• W69440101 hasConcept C2779705218 @default.
• W69440101 hasConcept C2780007613 @default.
• W69440101 hasConcept C28328180 @default.
• W69440101 hasConcept C67662055 @default.
• W69440101 hasConcept C74172505 @default.
• W69440101 hasConcept C86803240 @default.
• W69440101 hasConcept C8891405 @default.
• W69440101 hasConcept C95444343 @default.
• W69440101 hasConceptScore W69440101C109159458 @default.
• W69440101 hasConceptScore W69440101C131665280 @default.
• W69440101 hasConceptScore W69440101C153911025 @default.
• W69440101 hasConceptScore W69440101C201750760 @default.
• W69440101 hasConceptScore W69440101C203014093 @default.
• W69440101 hasConceptScore W69440101C2776090121 @default.
• W69440101 hasConceptScore W69440101C2777478134 @default.
• W69440101 hasConceptScore W69440101C2777863708 @default.
• W69440101 hasConceptScore W69440101C2777918643 @default.
• W69440101 hasConceptScore W69440101C2777983669 @default.
• W69440101 hasConceptScore W69440101C2778690821 @default.
• W69440101 hasConceptScore W69440101C2779705218 @default.
• W69440101 hasConceptScore W69440101C2780007613 @default.
• W69440101 hasConceptScore W69440101C28328180 @default.
• W69440101 hasConceptScore W69440101C67662055 @default.
• W69440101 hasConceptScore W69440101C74172505 @default.
• W69440101 hasConceptScore W69440101C86803240 @default.
• W69440101 hasConceptScore W69440101C8891405 @default.
• W69440101 hasConceptScore W69440101C95444343 @default.
• W69440101 hasLocation W694401011 @default.
• W69440101 hasOpenAccess W69440101 @default.
• W69440101 hasPrimaryLocation W694401011 @default.
• W69440101 hasRelatedWork W1547038479 @default.
• W69440101 hasRelatedWork W157721590 @default.
• W69440101 hasRelatedWork W1825344511 @default.
• W69440101 hasRelatedWork W192651359 @default.

• next