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- W69632989 abstract "Objective: investigation of clinico-social and economic aspects of using amisulpride for the treatment of patients at early stages of schizophrenia and schizophrenic spectrum disorders with prevalent negative symptoms. Patients were treated in the Day Hospital (First Psychotic Episode Clinic) of the Moscow Research Institute of Psychiatry. Altogether 30 patients were included in this investigation. Solian was prescribed in doses varying from 300 to 1200 mg a day (mean 627,1±277 mg a day). Severity of disorders was evaluated by means of the PANSS while dynamics of social functioning and the quality of life parameters were measured by an original questionnaire. The measurements were taken before treatment and after 1, 3 and 6 months of using amisulpride. Cognitive characteristics were studied with the help of traditional tests for neuropsychological examination (A.Luria's school). Pharmacoeconomic five-year prognosis for maintenance treatment with Solian was based on mathematical modeling of the results of retrospective clinicoepidemiological and qualitative pharmacoepidemiological analysis and analysis of costs. For the calculation, the DATA™ 3.0 (Decision Analysis by TreeAge-Software for Pharmacoeconomics Modeling) package was used. Amisulpride demonstrated a specific spectrum of psychotropic activity, which differs it from other atypical antipsychotics. It brought about significant improvements of cognitive functioning, especially obvious after 6 months of treatment as well as improvement of social functioning, and, as a consequence, economical advantages of this drug." @default.
- W69632989 created "2016-06-24" @default.
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- W69632989 date "2005-01-01" @default.
- W69632989 modified "2023-09-24" @default.
- W69632989 title "Применение солидна на ранних этапах течения шизофрении (клинико-социальные и фармакоэкономические аспекты)" @default.
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