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- W69652892 abstract "In large part because of the comparative ease of genetic manipulation, the last 20 years have seen an exponential increase in the use of laboratory mice for behavioral research, with prominent genetic models available for neurodegenerative disease, and for directly manipulating and visualizing functional parameters in the living organism. Progress in understanding higher cognitive function in mice has however been hampered by several unique characteristics of this species, some of which become more challenging when examining age-related changes. Performance in several commonly used behavioral tasks is often influenced by noncognitive factors or preference for alternate strategies. Strain differences are prominent including in the manifestation of age-related sensorimotor impairments. Although previous research and commentary has sought to address these shortcomings, only recently have alternative testing procedures become more prominent. This chapter thus seeks to first rereview some of the underlying reasons to why the mouse may be ill-suited for rat-testing protocols, and summarize newer protocols which, if widely adopted, may address these long-standing issues and bring more consistency to the field. Finally, the last section will present a limited sample of studies that have already provided compelling data on cognitive aging despite the known challenges." @default.
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- W69652892 date "2008-11-04" @default.
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- W69652892 title "Mouse Models of Cognitive Aging: Behavioral Tasks and Neural Substrates" @default.
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