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• W6965533 abstract "Research Article2 September 1996free access Context dependent transactivation domains activate the immunoglobulin mu heavy chain gene enhancer. B. Erman B. Erman Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA 02254, USA. Search for more papers by this author R. Sen R. Sen Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA 02254, USA. Search for more papers by this author B. Erman B. Erman Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA 02254, USA. Search for more papers by this author R. Sen R. Sen Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA 02254, USA. Search for more papers by this author Author Information B. Erman1 and R. Sen1 1Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA 02254, USA. The EMBO Journal (1996)15:4665-4675https://doi.org/10.1002/j.1460-2075.1996.tb00843.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Enhancers and promoters nucleate the assembly of multiprotein complexes that are required for the transcriptional activation of eukaryotic genes. Although multimerized binding sites of individual transcription factors sometimes mimic the properties of an enhancer, the combinatorial use of factors is considered to be crucial for achieving biological specificity. The minimal B cell specific immunoglobulin mu heavy chain gene enhancer is activated by a combination of tissue-restricted ETS proteins and ubiquitously expressed basic helix-loop-helix transcription factors. Here we show that a domain of PU.1 that activates transcription from multimerized PU.1 binding sites is not required to activate the mu enhancer together with Ets-1. In contrast, a transactivation domain in Ets-1 is necessary to activate this enhancer synergistically with PU.1. Furthermore, the Ets-1 activation domain functions only when tethered to the muA site of the enhancer. These observations illuminate two forms of context dependence: first, all possible transcription activation domains may not be required to achieve combinatorial specificity; second, functional transcription activation domains may require appropriate positioning on DNA. Previous ArticleNext Article Volume 15Issue 171 September 1996In this issue RelatedDetailsLoading ..." @default.
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• W6965533 date "1996-09-01" @default.
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• W6965533 title "Context dependent transactivation domains activate the immunoglobulin mu heavy chain gene enhancer." @default.
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• W6965533 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00843.x" @default.
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