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- W69706663 abstract "Regulation of human B cell differentiation into antibody-secreting cells was studied. By utilizing monoclonal antibodies, B cells can be isolated into three subpopulations with respect to their activation stage: resting B cells, activated B cells, and B cells at the final differentiation stage. Anti-IgM together with BSF-1 activate resting B cells into the activated stage and activated B cells secrete BCGF and become responsive to BCGF. Then, BCDF (BSF-2) induces Ig secretion in activated B cells. cDNA for BSF-2 has been cloned and recombinant BSF-2 induced Ig secretion in B lymphoblastoid cells as well as in normal cells. The amino acid sequence deduced from the cDNA sequence does not have any homology with other lymphokines. Patients with cardiac myxoma often show autoantibody production. The result showed that cardiac myxoma cells secrete large amounts of BSF-2, indicating that constitutive production of BSF-2 in vivo may be responsible for autoantibody production." @default.
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- W69706663 date "1986-01-01" @default.
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- W69706663 title "Regulation of Human B Cell Differentiation: Molecular Structure and Immunological Functions of Human B Cell Differentiation Factor (BSF-2)" @default.
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- W69706663 doi "https://doi.org/10.1016/b978-0-12-174685-8.50038-x" @default.
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