Matches in SemOpenAlex for { <https://semopenalex.org/work/W69775146> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W69775146 endingPage "617" @default.
- W69775146 startingPage "615" @default.
- W69775146 abstract "The bridged tricyclic dopamine analogues exo -2-amino-5,8-dimethoxybenzobicyclo[2.2.2]octane, exo -2-( N,N -dipropylamino)-5,8-dimethoxybenzobicyclo[2.2.2]octane, exo -2-(dimethylamino)-5,8-dimethoxybenzobicyclo[2.2.2]octane and endo -2-amino-5,8-dimethoxybenzobicyclo[2.2.2]octane were tested for dopaminergic activity in vitro . Their affinity for [ 3 H]-spiroperidol binding sites in rat striatal membranes was compared to that of known active non-bridged dopamine agonists. Computer generated molecular models were used to examine whether the ethylene bridge acts as a steric hindrance to prevent the binding of these molecules to the receptor. Les analogues tricycliques pontés exo -amino-2-diméthoxy-5,8 benzobicyclo[2.2.2]octane, exo -( N,N -dipropylamino)-2-diméthoxy-5,8 benzobicyclo[2.2.2]octane, exo -(diméthylamino)-2-diméthoxy-5,8-benzobicyclo[2.2.2]octane, et endo -amino-2-diméthoxy-5,8 benzobicyclo[2.2.2]octane, de la dopamine ont été essayés pour leur activité dopaminergique in vitro . Leur affinité pour les sites de liaison du [ 3 H]spiropéridol dans les membranes du corps strié du Rat a été comparée avec celle des agonistes connus, non pontés de la dopamine. Des modèles moléculaires synthétisés par ordinateur ont été utilisés pour élucider si le pont éthylénique intervenait comme gêne stérique pour empêcher la liaison de ces molécules au récepteur." @default.
- W69775146 created "2016-06-24" @default.
- W69775146 creator A5003690173 @default.
- W69775146 creator A5047902127 @default.
- W69775146 date "1989-12-01" @default.
- W69775146 modified "2023-10-16" @default.
- W69775146 title "Synthèse et propriétés dopaminergiques d'analogues tricycliques pontés de la dopamine" @default.
- W69775146 cites W1954038986 @default.
- W69775146 cites W1975761285 @default.
- W69775146 cites W1977274604 @default.
- W69775146 cites W2068388570 @default.
- W69775146 cites W2082192583 @default.
- W69775146 cites W2093227162 @default.
- W69775146 cites W2294946349 @default.
- W69775146 cites W2315351629 @default.
- W69775146 doi "https://doi.org/10.1016/0223-5234(89)90030-5" @default.
- W69775146 hasPublicationYear "1989" @default.
- W69775146 type Work @default.
- W69775146 sameAs 69775146 @default.
- W69775146 citedByCount "1" @default.
- W69775146 crossrefType "journal-article" @default.
- W69775146 hasAuthorship W69775146A5003690173 @default.
- W69775146 hasAuthorship W69775146A5047902127 @default.
- W69775146 hasConcept C137183658 @default.
- W69775146 hasConcept C15744967 @default.
- W69775146 hasConcept C169760540 @default.
- W69775146 hasConcept C178790620 @default.
- W69775146 hasConcept C185592680 @default.
- W69775146 hasConcept C2776624427 @default.
- W69775146 hasConcept C513476851 @default.
- W69775146 hasConcept C71240020 @default.
- W69775146 hasConceptScore W69775146C137183658 @default.
- W69775146 hasConceptScore W69775146C15744967 @default.
- W69775146 hasConceptScore W69775146C169760540 @default.
- W69775146 hasConceptScore W69775146C178790620 @default.
- W69775146 hasConceptScore W69775146C185592680 @default.
- W69775146 hasConceptScore W69775146C2776624427 @default.
- W69775146 hasConceptScore W69775146C513476851 @default.
- W69775146 hasConceptScore W69775146C71240020 @default.
- W69775146 hasIssue "6" @default.
- W69775146 hasLocation W697751461 @default.
- W69775146 hasOpenAccess W69775146 @default.
- W69775146 hasPrimaryLocation W697751461 @default.
- W69775146 hasRelatedWork W1971049320 @default.
- W69775146 hasRelatedWork W1984600212 @default.
- W69775146 hasRelatedWork W2022377607 @default.
- W69775146 hasRelatedWork W2053807370 @default.
- W69775146 hasRelatedWork W2084860270 @default.
- W69775146 hasRelatedWork W2093078804 @default.
- W69775146 hasRelatedWork W2154314448 @default.
- W69775146 hasRelatedWork W2334383820 @default.
- W69775146 hasRelatedWork W2344558391 @default.
- W69775146 hasRelatedWork W2951805389 @default.
- W69775146 hasVolume "24" @default.
- W69775146 isParatext "false" @default.
- W69775146 isRetracted "false" @default.
- W69775146 magId "69775146" @default.
- W69775146 workType "article" @default.