Matches in SemOpenAlex for { <https://semopenalex.org/work/W69779785> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W69779785 abstract "Aim: A single nucleotide polymorphism on chromosome 9p21, rs10757274 (9p21 allele), has been shown to be a predictor of coronary heart disease (CHD) in whites. We evaluated if the addition of the 9p21 allele to traditional risk factors (TRF) improved CHD risk prediction in the white population of the Atherosclerosis Risk in Communities (ARIC) study, and whether changes in risk prediction will modify lipid therapy recommendation. Methods: Whites (n=10,004) in the ARIC study for whom the 9p21 genotype and TRF (age, gender, systolic blood pressure, total cholesterol, smoking, diabetes, HDL-C, and anti-hypertensive medication use) information was available were included. Using Cox proportional hazards models, the ARIC Cardiovascular Risk Score (ACRS) which is based on TRF was determined. The impact of adding the 9p21 allele to TRF with respect to the area under the curve (AUC) of a receiver operating characteristic (ROC) curve and then risk strata reclassification was determined. Results: The addition of 9p21 allele to TRF was associated with a hazard ratio (HR) of 1.25 (p<0.0001) and an increase in the AUC for incident CHD from 0.776 to 0.780 (Δ= 0.004, 95% CI=0.001, 0.008). The 9p21 allele’s greatest influence to the ACRS (Table ) was observed in the intermediate (5–10% 10-year CHD risk) and intermediate-high (10 –20% 10-year CHD risk) categories with 19.3% and 16.9% reclassified, respectively, which would impact therapy, as approximately 90% of these individuals had LDL-C >100 mg/dL. Table: Reclassification in the different ACRS categories after the addition of the 9p21 allele to the traditional risk factors" @default.
- W69779785 created "2016-06-24" @default.
- W69779785 creator A5006049651 @default.
- W69779785 creator A5028907710 @default.
- W69779785 creator A5041389697 @default.
- W69779785 creator A5045515686 @default.
- W69779785 creator A5046471463 @default.
- W69779785 creator A5075061959 @default.
- W69779785 creator A5078180084 @default.
- W69779785 creator A5083705396 @default.
- W69779785 date "2008-10-28" @default.
- W69779785 modified "2023-10-17" @default.
- W69779785 title "Abstract 5090: Impact of Adding a Single Allele in the 9p21 Locus to Traditional Risk Factors on Risk Classification for Coronary Heart Disease and Implications for Lipid-Modifying Therapy in the White Population of the Atherosclerosis Risk in Communities (ARIC) Study" @default.
- W69779785 doi "https://doi.org/10.1161/circ.118.suppl_18.s_1143-b" @default.
- W69779785 hasPublicationYear "2008" @default.
- W69779785 type Work @default.
- W69779785 sameAs 69779785 @default.
- W69779785 citedByCount "4" @default.
- W69779785 crossrefType "journal-article" @default.
- W69779785 hasAuthorship W69779785A5006049651 @default.
- W69779785 hasAuthorship W69779785A5028907710 @default.
- W69779785 hasAuthorship W69779785A5041389697 @default.
- W69779785 hasAuthorship W69779785A5045515686 @default.
- W69779785 hasAuthorship W69779785A5046471463 @default.
- W69779785 hasAuthorship W69779785A5075061959 @default.
- W69779785 hasAuthorship W69779785A5078180084 @default.
- W69779785 hasAuthorship W69779785A5083705396 @default.
- W69779785 hasConcept C104317684 @default.
- W69779785 hasConcept C11783203 @default.
- W69779785 hasConcept C126322002 @default.
- W69779785 hasConcept C135763542 @default.
- W69779785 hasConcept C143998085 @default.
- W69779785 hasConcept C164705383 @default.
- W69779785 hasConcept C180754005 @default.
- W69779785 hasConcept C207103383 @default.
- W69779785 hasConcept C2779134260 @default.
- W69779785 hasConcept C2908647359 @default.
- W69779785 hasConcept C44249647 @default.
- W69779785 hasConcept C50382708 @default.
- W69779785 hasConcept C54355233 @default.
- W69779785 hasConcept C58471807 @default.
- W69779785 hasConcept C71924100 @default.
- W69779785 hasConcept C84597430 @default.
- W69779785 hasConcept C86803240 @default.
- W69779785 hasConcept C99454951 @default.
- W69779785 hasConceptScore W69779785C104317684 @default.
- W69779785 hasConceptScore W69779785C11783203 @default.
- W69779785 hasConceptScore W69779785C126322002 @default.
- W69779785 hasConceptScore W69779785C135763542 @default.
- W69779785 hasConceptScore W69779785C143998085 @default.
- W69779785 hasConceptScore W69779785C164705383 @default.
- W69779785 hasConceptScore W69779785C180754005 @default.
- W69779785 hasConceptScore W69779785C207103383 @default.
- W69779785 hasConceptScore W69779785C2779134260 @default.
- W69779785 hasConceptScore W69779785C2908647359 @default.
- W69779785 hasConceptScore W69779785C44249647 @default.
- W69779785 hasConceptScore W69779785C50382708 @default.
- W69779785 hasConceptScore W69779785C54355233 @default.
- W69779785 hasConceptScore W69779785C58471807 @default.
- W69779785 hasConceptScore W69779785C71924100 @default.
- W69779785 hasConceptScore W69779785C84597430 @default.
- W69779785 hasConceptScore W69779785C86803240 @default.
- W69779785 hasConceptScore W69779785C99454951 @default.
- W69779785 hasIssue "suppl_18" @default.
- W69779785 hasLocation W697797851 @default.
- W69779785 hasOpenAccess W69779785 @default.
- W69779785 hasPrimaryLocation W697797851 @default.
- W69779785 hasRelatedWork W2019275960 @default.
- W69779785 hasRelatedWork W2213857236 @default.
- W69779785 hasRelatedWork W3030770765 @default.
- W69779785 hasRelatedWork W3032663536 @default.
- W69779785 hasRelatedWork W3068060963 @default.
- W69779785 hasRelatedWork W3102307445 @default.
- W69779785 hasRelatedWork W3158644626 @default.
- W69779785 hasRelatedWork W4214717482 @default.
- W69779785 hasRelatedWork W4226372519 @default.
- W69779785 hasRelatedWork W45608586 @default.
- W69779785 hasVolume "118" @default.
- W69779785 isParatext "false" @default.
- W69779785 isRetracted "false" @default.
- W69779785 magId "69779785" @default.
- W69779785 workType "article" @default.