Matches in SemOpenAlex for { <https://semopenalex.org/work/W69782743> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W69782743 abstract "The interactions between polymers and components of biological systems are an important area of interest within the fields of tissue engineering, polymer chemistry, medicine and biomaterials. In order to create such a biomimetic material, it must show the inherent ability to reproduce or elicit a biological function. How do we design synthetic materials in order to direct their interactions with biological systems?This thesis contributes to this research with aspects of how polymers interact with biological materials with the help of ionic interactions. Polyesters, biodegradable or not, may after a hydrolytic cleavage interact ionically with protonated amines by the liberated carboxylate functions. Amines are found in proteins and this fact will help us to anchor proteins to polyester surfaces. Another type of interaction is to culture cells in polymeric materials, i.e. scaffolds. We have been working on compliant substrates, knitted structures, to allow cell culture in three dimensions. A problem that arises here is how to get a high cell seeding efficiency? By working on the interactions between polymers, proteins and finally cells, it is possible to create a polarized protein membrane that allows for very efficient cell seeding, and subsequent three dimensional cell cultures. Finally a synthetic route to taylor interaction was developed. Here a group of polymers known as ionomers were synthesized. In our case ionic end groups have been placed onto biodegradable polycarbonates, we have created amphiphilic telechelic ionomers. Functionalization, anionic or cationic, changes the properties of the material in many ways due to aggregation and surface enrichment of ionic groups. It is possible to add functional groups for a variety of different interactions, for example introducing ionic groups that interact and bind to the complementary charge of proteins or on the other hand one can chose groups to prevent protein interactions, like the phosphorylcholine zwitterionomers. Such interactions can be utilized to modulate the release of proteins from these materials when used in protein delivery applications. The swelling properties, Tg, degradation rate and mechanical properties are among other things that will easily be altered with the choice of functional groups or backbone polymer." @default.
- W69782743 created "2016-06-24" @default.
- W69782743 creator A5026337266 @default.
- W69782743 creator A5056089992 @default.
- W69782743 creator A5082708448 @default.
- W69782743 creator A5090479483 @default.
- W69782743 date "2006-01-01" @default.
- W69782743 modified "2023-09-24" @default.
- W69782743 title "Swelling behaviour of biodegradable ionomers" @default.
- W69782743 hasPublicationYear "2006" @default.
- W69782743 type Work @default.
- W69782743 sameAs 69782743 @default.
- W69782743 citedByCount "0" @default.
- W69782743 crossrefType "journal-article" @default.
- W69782743 hasAuthorship W69782743A5026337266 @default.
- W69782743 hasAuthorship W69782743A5056089992 @default.
- W69782743 hasAuthorship W69782743A5082708448 @default.
- W69782743 hasAuthorship W69782743A5090479483 @default.
- W69782743 hasConcept C115537861 @default.
- W69782743 hasConcept C119394753 @default.
- W69782743 hasConcept C126348684 @default.
- W69782743 hasConcept C127413603 @default.
- W69782743 hasConcept C145148216 @default.
- W69782743 hasConcept C15920480 @default.
- W69782743 hasConcept C159985019 @default.
- W69782743 hasConcept C171250308 @default.
- W69782743 hasConcept C178790620 @default.
- W69782743 hasConcept C183882617 @default.
- W69782743 hasConcept C185592680 @default.
- W69782743 hasConcept C188027245 @default.
- W69782743 hasConcept C192562407 @default.
- W69782743 hasConcept C2182769 @default.
- W69782743 hasConcept C42360764 @default.
- W69782743 hasConcept C521977710 @default.
- W69782743 hasConcept C67407626 @default.
- W69782743 hasConceptScore W69782743C115537861 @default.
- W69782743 hasConceptScore W69782743C119394753 @default.
- W69782743 hasConceptScore W69782743C126348684 @default.
- W69782743 hasConceptScore W69782743C127413603 @default.
- W69782743 hasConceptScore W69782743C145148216 @default.
- W69782743 hasConceptScore W69782743C15920480 @default.
- W69782743 hasConceptScore W69782743C159985019 @default.
- W69782743 hasConceptScore W69782743C171250308 @default.
- W69782743 hasConceptScore W69782743C178790620 @default.
- W69782743 hasConceptScore W69782743C183882617 @default.
- W69782743 hasConceptScore W69782743C185592680 @default.
- W69782743 hasConceptScore W69782743C188027245 @default.
- W69782743 hasConceptScore W69782743C192562407 @default.
- W69782743 hasConceptScore W69782743C2182769 @default.
- W69782743 hasConceptScore W69782743C42360764 @default.
- W69782743 hasConceptScore W69782743C521977710 @default.
- W69782743 hasConceptScore W69782743C67407626 @default.
- W69782743 hasLocation W697827431 @default.
- W69782743 hasOpenAccess W69782743 @default.
- W69782743 hasPrimaryLocation W697827431 @default.
- W69782743 hasRelatedWork W1482284493 @default.
- W69782743 hasRelatedWork W1546717361 @default.
- W69782743 hasRelatedWork W1977777172 @default.
- W69782743 hasRelatedWork W1984327089 @default.
- W69782743 hasRelatedWork W2096543123 @default.
- W69782743 hasRelatedWork W2115875222 @default.
- W69782743 hasRelatedWork W2158233883 @default.
- W69782743 hasRelatedWork W2166075587 @default.
- W69782743 hasRelatedWork W2313137091 @default.
- W69782743 hasRelatedWork W2321846504 @default.
- W69782743 hasRelatedWork W2570875533 @default.
- W69782743 hasRelatedWork W2888061835 @default.
- W69782743 hasRelatedWork W2901771198 @default.
- W69782743 hasRelatedWork W2903761953 @default.
- W69782743 hasRelatedWork W2952062125 @default.
- W69782743 hasRelatedWork W3092577317 @default.
- W69782743 hasRelatedWork W3110304959 @default.
- W69782743 hasRelatedWork W3152840300 @default.
- W69782743 hasRelatedWork W319502750 @default.
- W69782743 hasRelatedWork W2189255685 @default.
- W69782743 isParatext "false" @default.
- W69782743 isRetracted "false" @default.
- W69782743 magId "69782743" @default.
- W69782743 workType "article" @default.