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- W69784438 abstract "Wegener’s granulomatosis (WG), a systemic necrotizing granulomatous vasculitis, used to be considered a relatively rare disease, but in the past few years it has been diagnosed much more frequently. This is at least partially due to the study by Van der Woude et al. (1985), who showed that autoantibodies directed against a cytoplasmic antigen of human neutrophil granulocytes and monocytes (anti-cytoplasmic antibodies = ACPA, synonym: ANCA; C-ANCA) are a disease-specific marker of WG. The im-munodiagnostic value of ACPA has been confirmed by many investigators (Gross et al., 1986; Savage et al., 1987; Lüdemann and Gross, 1987; Parlevliet et al., 1988). Moreover, it has been shown that changes in ACPA titer parallel changes in disease activity (Van der Woude et al., 1985; Parlevliet et al., 1988; Lüdemann et al., 1988a; Specks et al., 1989; Nölle et al., 1989)." @default.
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- W69784438 date "1991-01-01" @default.
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- W69784438 title "Anti-Cytoplasmic Antibodies in Wegener’s Granulomatosis are Directed Against Proteinase 3" @default.
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- W69784438 doi "https://doi.org/10.1007/978-1-4899-3629-5_12" @default.
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