FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W69815557> ?p ?o ?g. }

• W69815557 endingPage "156" @default.
• W69815557 startingPage "121" @default.
• W69815557 abstract "T cells develop from bone marrow-derived self-renewing hematopoietic stem cells (HSC). Upon entering the thymus, these cells undergo progressive commitment and differentiation driven by the thymic stroma and the pre-T cell receptor (pre-TCR). These processes are disrupted in T-cell acute lymphoblastic leukemia (T-ALL). More than 70% of recurring chromosomal rearrangements in T-ALL activate the expression of oncogenic transcription factors, belonging mostly to three families, basic helix-loop-helix (bHLH), homeobox (HOX), and c-MYB. This prevalence is indicative of their importance in the T lineage, and their dominant mechanisms of transformation. For example, bHLH oncoproteins inhibit E2A and HEB, revealing their tumor suppressor function in the thymus. The induction of T-ALL, nonetheless, requires collaboration with constitutive NOTCH1 signaling and the pre-TCR, as well as loss-of-function mutations for CDKN2A and PTEN. Significantly, NOTCH1, the pre-TCR pathway, and E2A/HEB proteins control critical checkpoints and branchpoints in early thymocyte development whereas several oncogenic transcription factors, HOXA9, c-MYB, SCL, and LYL-1 control HSC self-renewal. Together, these genetic lesions alter key regulatory processes in the cell, favoring self-renewal and subvert the normal control of thymocyte homeostasis." @default.
• W69815557 created "2016-06-24" @default.
• W69815557 creator A5068868190 @default.
• W69815557 creator A5076143416 @default.
• W69815557 creator A5083099238 @default.
• W69815557 date "2010-01-01" @default.
• W69815557 modified "2023-10-18" @default.
• W69815557 title "Early T Cell Differentiation" @default.
• W69815557 cites W1479717491 @default.
• W69815557 cites W1492026543 @default.
• W69815557 cites W1506183674 @default.
• W69815557 cites W1566064342 @default.
• W69815557 cites W1581345953 @default.
• W69815557 cites W1605939038 @default.
• W69815557 cites W1661988322 @default.
• W69815557 cites W1672865967 @default.
• W69815557 cites W1804861156 @default.
• W69815557 cites W1920024920 @default.
• W69815557 cites W1966152616 @default.
• W69815557 cites W1966179399 @default.
• W69815557 cites W1966828612 @default.
• W69815557 cites W1967059605 @default.
• W69815557 cites W1974200066 @default.
• W69815557 cites W1974870158 @default.
• W69815557 cites W1976021347 @default.
• W69815557 cites W1977706798 @default.
• W69815557 cites W1978114830 @default.
• W69815557 cites W1979211157 @default.
• W69815557 cites W1979798449 @default.
• W69815557 cites W1980212327 @default.
• W69815557 cites W1981344753 @default.
• W69815557 cites W1981896461 @default.
• W69815557 cites W1982767015 @default.
• W69815557 cites W1983117122 @default.
• W69815557 cites W1983507527 @default.
• W69815557 cites W1984885351 @default.
• W69815557 cites W1990184382 @default.
• W69815557 cites W1991615434 @default.
• W69815557 cites W1992051385 @default.
• W69815557 cites W1993358535 @default.
• W69815557 cites W1994219810 @default.
• W69815557 cites W1994791278 @default.
• W69815557 cites W1995421851 @default.
• W69815557 cites W1996088639 @default.
• W69815557 cites W1999547931 @default.
• W69815557 cites W2000589976 @default.
• W69815557 cites W2000775754 @default.
• W69815557 cites W2003097999 @default.
• W69815557 cites W200461798 @default.
• W69815557 cites W2007525719 @default.
• W69815557 cites W2010445222 @default.
• W69815557 cites W2011497780 @default.
• W69815557 cites W2011984142 @default.
• W69815557 cites W2014345967 @default.
• W69815557 cites W2015003693 @default.
• W69815557 cites W2016507620 @default.
• W69815557 cites W2018527149 @default.
• W69815557 cites W2019361551 @default.
• W69815557 cites W2020002041 @default.
• W69815557 cites W2020713861 @default.
• W69815557 cites W2022668368 @default.
• W69815557 cites W2023014537 @default.
• W69815557 cites W2023332575 @default.
• W69815557 cites W2023601085 @default.
• W69815557 cites W2023920753 @default.
• W69815557 cites W2024754664 @default.
• W69815557 cites W2025645148 @default.
• W69815557 cites W2025783409 @default.
• W69815557 cites W2027241628 @default.
• W69815557 cites W2028735719 @default.
• W69815557 cites W2028885330 @default.
• W69815557 cites W2032095580 @default.
• W69815557 cites W2032534720 @default.
• W69815557 cites W2033091093 @default.
• W69815557 cites W2033681375 @default.
• W69815557 cites W2035444177 @default.
• W69815557 cites W2035543586 @default.
• W69815557 cites W2037688286 @default.
• W69815557 cites W2037856863 @default.
• W69815557 cites W2038943607 @default.
• W69815557 cites W2039096008 @default.
• W69815557 cites W2040171134 @default.
• W69815557 cites W2040329520 @default.
• W69815557 cites W2040586689 @default.
• W69815557 cites W2041175983 @default.
• W69815557 cites W2042046416 @default.
• W69815557 cites W2042108397 @default.
• W69815557 cites W2044499590 @default.
• W69815557 cites W2045243107 @default.
• W69815557 cites W2046928493 @default.
• W69815557 cites W2047465993 @default.
• W69815557 cites W2048365283 @default.
• W69815557 cites W2048613921 @default.
• W69815557 cites W2048835029 @default.
• W69815557 cites W2049396238 @default.
• W69815557 cites W2052568445 @default.
• W69815557 cites W2053734578 @default.
• W69815557 cites W2053813270 @default.

• next