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• W6984513 abstract "Primary carcinogenic changes involve mutations in genes which contribute to the ordered events that control the eucaryotic cell cycle. It has been demonstrated that many protooncogenes take part in the regulation of cell growth. Pradl, for instance, has been identified as cyclin Dl. Myc is involved in early cell cycle events while p53, one of the growing number of tumor suppressors, blocks the cell cycle in Gl in response to DNA damage. These proteins interfere with certain cell cycle control elements and cause either induction or repression of specific regulatory events. However, when mutated these regulators may be unable to fulfill their proper function which can then lead to inappropriate cell cycle progression. This may result in cell death or in transformation from quiescence to uncontrolled proliferation. Thus, the investigation of the cell cycle will lead to a better understanding of the molecular events which result in malignant cell growth." @default.
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• W6984513 date "1997-01-01" @default.
• W6984513 modified "2023-09-27" @default.
• W6984513 title "New Cell Cycle-Regulated Genes in the Yeast Saccharomyces cerevisiae" @default.
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• W6984513 doi "https://doi.org/10.1007/978-3-642-60393-8_18" @default.
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