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- W69862788 abstract "The presently employed components of HAART are derived from a variety of chemically and pharmacologically different drug classes. The first compounds, which possessed antiretroviral activity were designed as nucleoside analogues in order to inhibit the reverse transcriptase. The first drug zidovudine (AZT) became available in 1987 and was followed soon by several compounds, which were directed at the same pharmacological target and derived from the same chemical class. The early experiences with nucleoside analogues (NRTI) in the course of antiviral treatment revealed a number of limitations: The medication had to be administered frequently at high doses with a considerable number of adverse effects. The most significant clinical restriction, however represented the emergence of mutant virus strains, which led to a partial or complete loss of activity. Consequently NRTI were combined at full doses, e.g., AZT with 3TC (lamivudine) or ddI (didanosine) with d4T (stavudine), which led to a higher antiviral potency and a prolonged period of time until mutations occurred in treated patients." @default.
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- W69862788 date "2004-01-01" @default.
- W69862788 modified "2023-09-23" @default.
- W69862788 title "Pharmacokinetics and pharmacodynamics of HAART" @default.
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- W69862788 doi "https://doi.org/10.1007/978-3-0348-7869-2_5" @default.
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