FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W69876515> ?p ?o ?g. }

• W69876515 endingPage "255" @default.
• W69876515 startingPage "249" @default.
• W69876515 abstract "Background: In Italy, antiretroviral combination therapy was adopted in mid-1995 and protease inhibitors in mid-1996. Objective: To conduct a prospective, population-based, observational study to evaluate the effect of these therapies on the survival of persons with AIDS (PWA). Methods: PWA living in the Tuscany region diagnosed between 1985 and 31 March 1997 (National AIDS Registry) were studied. Information on antiretroviral drugs, prophylactic treatment, CD4 cell count, and AIDS-defining illnesses was collected for PWA still alive at 1 January 1996 and those diagnosed thereafter (analysis cut-off date, 30 November 1997). Kaplan-Meier curves were calculated by year of diagnosis. A Cox model was then used to estimate the adjusted (by sex, age, HIV exposure category, CD4 cell count, type and number of AIDS-defining illnesses) relative hazard (RH) of death by year of diagnosis and calendar date (considered as a time-dependent variable). Similar analyses were repeated for PWA diagnosed after 1989, having been stratified by disease-specific AIDS condition. A final analysis was performed for PWA still alive at 1 January 1996 or diagnosed thereafter for estimating the effect of single, double and triple combination therapy (time-dependent variables), having adjusted for the above variables and for prophylactic treatment. Results: A total of 1683 (79.5%) out of 2118 PWA died before 1 December 1997. Use of more potent combination therapies, including protease inhibitors, greatly increased during 1997. Median survival was 2.9, 12.3, 13.4, 11.4 and 17.6 months for diagnoses before 1987, in 1987-1990, 1991-1993, 1994 and 1995, respectively; an estimated 62% of those diagnosed in 1996-1997 had survived 15 months after diagnosis. The Cox model showed a trend of decrease of RH for calendar time starting in the first half of 1996, compared with 1994. When stratifying by specific AIDS-defining disease there was no statistically significant evidence that the improved overall survival was due to increased survival only for certain diseases. The final multivariate analysis for the 771 PWA still alive at 1 January 1996 or diagnosed thereafter estimated significant RH <1.0 for double and triple therapy (RH, 0.61 and 0.36, respectively) compared with no therapy. Conclusions: A significant reduction in risk of death after AIDS was observed from the second half of 1996, apparently due to the widespread use of antiretroviral combination therapies." @default.
• W69876515 created "2016-06-24" @default.
• W69876515 creator A5009879212 @default.
• W69876515 creator A5013540701 @default.
• W69876515 creator A5042919720 @default.
• W69876515 creator A5052579386 @default.
• W69876515 creator A5054065169 @default.
• W69876515 creator A5061408760 @default.
• W69876515 creator A5076922621 @default.
• W69876515 date "1999-02-01" @default.
• W69876515 modified "2023-10-11" @default.
• W69876515 title "Increasing survival time after AIDS in Italy: the role of new combination antiretroviral therapies" @default.
• W69876515 cites W12398257 @default.
• W69876515 cites W148835879 @default.
• W69876515 cites W1735143085 @default.
• W69876515 cites W1791338516 @default.
• W69876515 cites W1862056775 @default.
• W69876515 cites W1969342241 @default.
• W69876515 cites W1989041073 @default.
• W69876515 cites W2014859893 @default.
• W69876515 cites W2080704165 @default.
• W69876515 cites W2099509337 @default.
• W69876515 cites W2123227598 @default.
• W69876515 cites W2136390349 @default.
• W69876515 cites W2169348402 @default.
• W69876515 cites W2318289184 @default.
• W69876515 cites W2319972101 @default.
• W69876515 cites W2339219218 @default.
• W69876515 cites W4230586965 @default.
• W69876515 cites W4238996976 @default.
• W69876515 cites W4245336654 @default.
• W69876515 cites W4255512423 @default.
• W69876515 doi "https://doi.org/10.1097/00002030-199902040-00013" @default.
• W69876515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10885782" @default.
• W69876515 hasPublicationYear "1999" @default.
• W69876515 type Work @default.
• W69876515 sameAs 69876515 @default.
• W69876515 citedByCount "129" @default.
• W69876515 countsByYear W698765152012 @default.
• W69876515 countsByYear W698765152013 @default.
• W69876515 countsByYear W698765152014 @default.
• W69876515 countsByYear W698765152015 @default.
• W69876515 countsByYear W698765152017 @default.
• W69876515 countsByYear W698765152018 @default.
• W69876515 countsByYear W698765152020 @default.
• W69876515 crossrefType "journal-article" @default.
• W69876515 hasAuthorship W69876515A5009879212 @default.
• W69876515 hasAuthorship W69876515A5013540701 @default.
• W69876515 hasAuthorship W69876515A5042919720 @default.
• W69876515 hasAuthorship W69876515A5052579386 @default.
• W69876515 hasAuthorship W69876515A5054065169 @default.
• W69876515 hasAuthorship W69876515A5061408760 @default.
• W69876515 hasAuthorship W69876515A5076922621 @default.
• W69876515 hasBestOaLocation W698765151 @default.
• W69876515 hasConcept C10515644 @default.
• W69876515 hasConcept C126322002 @default.
• W69876515 hasConcept C187212893 @default.
• W69876515 hasConcept C203014093 @default.
• W69876515 hasConcept C207103383 @default.
• W69876515 hasConcept C23131810 @default.
• W69876515 hasConcept C2776452011 @default.
• W69876515 hasConcept C2780727368 @default.
• W69876515 hasConcept C2908647359 @default.
• W69876515 hasConcept C3013748606 @default.
• W69876515 hasConcept C44249647 @default.
• W69876515 hasConcept C50382708 @default.
• W69876515 hasConcept C71924100 @default.
• W69876515 hasConcept C99454951 @default.
• W69876515 hasConceptScore W69876515C10515644 @default.
• W69876515 hasConceptScore W69876515C126322002 @default.
• W69876515 hasConceptScore W69876515C187212893 @default.
• W69876515 hasConceptScore W69876515C203014093 @default.
• W69876515 hasConceptScore W69876515C207103383 @default.
• W69876515 hasConceptScore W69876515C23131810 @default.
• W69876515 hasConceptScore W69876515C2776452011 @default.
• W69876515 hasConceptScore W69876515C2780727368 @default.
• W69876515 hasConceptScore W69876515C2908647359 @default.
• W69876515 hasConceptScore W69876515C3013748606 @default.
• W69876515 hasConceptScore W69876515C44249647 @default.
• W69876515 hasConceptScore W69876515C50382708 @default.
• W69876515 hasConceptScore W69876515C71924100 @default.
• W69876515 hasConceptScore W69876515C99454951 @default.
• W69876515 hasIssue "2" @default.
• W69876515 hasLocation W698765151 @default.
• W69876515 hasLocation W698765152 @default.
• W69876515 hasLocation W698765153 @default.
• W69876515 hasOpenAccess W69876515 @default.
• W69876515 hasPrimaryLocation W698765151 @default.
• W69876515 hasRelatedWork W2010631330 @default.
• W69876515 hasRelatedWork W2026784993 @default.
• W69876515 hasRelatedWork W2581226876 @default.
• W69876515 hasRelatedWork W2994686985 @default.
• W69876515 hasRelatedWork W3136232645 @default.
• W69876515 hasRelatedWork W4225134093 @default.
• W69876515 hasRelatedWork W4281722959 @default.
• W69876515 hasRelatedWork W4379796428 @default.
• W69876515 hasRelatedWork W4380269519 @default.
• W69876515 hasRelatedWork W4380448775 @default.

• next