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- W69992011 abstract "The low incidence of drug-induced liver injury (DILI), along with the difficulty in establishing a diagnosis, has hampered our ability to study the molecular pathogenesis of drug and herbal hepatotoxicity. Multicenter research networks have recently been developed in the United States and other countries to facilitate further research into this uncommon but important adverse drug reaction. Currently, several prospective registries including the Drug-Induced Liver Injury Network utilize standardized definitions, phenotyping, and causality assessment methods in ongoing studies of host immunological, genetic, and environmental factors in DILI pathogenesis and outcome. The increasing use of electronic medical records coupled with the application of natural language processing algorithms may further help identify DILI patients for future studies. Finally, continuing advances in genomic methods may allow us to better identify risk factors for DILI susceptibility and diagnosis, which should help to mitigate the risk for individual patients in the years to come." @default.
- W69992011 created "2016-06-24" @default.
- W69992011 creator A5063597784 @default.
- W69992011 date "2013-01-01" @default.
- W69992011 modified "2023-09-26" @default.
- W69992011 title "Drug-Induced Liver Injury Research Networks" @default.
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- W69992011 doi "https://doi.org/10.1016/b978-0-12-387817-5.00039-x" @default.
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