FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W70001411> ?p ?o ?g. }

• W70001411 endingPage "6" @default.
• W70001411 startingPage "2293" @default.
• W70001411 abstract "The human cornea, a tissue much exposed to oxidative stress, is rich in extracellular superoxide dismutase (SOD). In this study, the contents and distributions of the SOD isoenzymes in the normal human cornea were compared with those in corneas affected by keratoconus and bullous keratopathy.The central and peripheral parts of normal human corneas were analyzed separately. Central corneal buttons were obtained from patients with keratoconus and bullous keratopathy who were undergoing primary keratoplasty or retransplantation. SOD enzymatic activities were determined by a direct spectrophotometric method, and extracellular SOD and the cytosolic Cu- and Zn-containing SOD (CuZn-SOD) proteins were determined with ELISA and studied with immunohistochemistry.The total SOD content, and particularly the extracellular SOD content, was lower in the central than in the peripheral normal cornea. CuZn-SOD and extracellular SOD were demonstrated in all three corneal layers. CuZn-SOD was found in cells, whereas extracellular SOD appeared to be localized on cell surfaces, in basal membranes, and in the stroma. In keratoconus, corneal levels of extracellular SOD were half those in the control corneas, whereas CuZn-SOD and the mitochondrial Mn-containing SOD levels were normal. In bullous keratopathy, apart from edematous dilution, SOD isoenzyme levels were essentially normal. In a remarkable finding, the same pattern in SOD isoenzyme levels as in the original disease was also found at retransplantation.Extracellular SOD and CuZn-SOD show markedly different distribution patterns within the human cornea. Extracellular SOD activity in the central cornea is halved in keratoconus, compared with that in normal control corneas. The finding of a similar reduction at retransplantation in keratoconus suggests reduced corneal extracellular SOD synthesis in cells of the host as a cause of the low enzyme levels." @default.
• W70001411 created "2016-06-24" @default.
• W70001411 creator A5000503977 @default.
• W70001411 creator A5010748442 @default.
• W70001411 creator A5031486216 @default.
• W70001411 creator A5041065588 @default.
• W70001411 creator A5049517490 @default.
• W70001411 date "2001-09-01" @default.
• W70001411 modified "2023-09-23" @default.
• W70001411 title "Superoxide dismutase isoenzymes in the normal and diseased human cornea." @default.
• W70001411 cites W105779266 @default.
• W70001411 cites W1526828761 @default.
• W70001411 cites W1536516181 @default.
• W70001411 cites W1544779194 @default.
• W70001411 cites W1554089382 @default.
• W70001411 cites W1570707523 @default.
• W70001411 cites W1572685041 @default.
• W70001411 cites W1576198188 @default.
• W70001411 cites W1580541669 @default.
• W70001411 cites W1940436875 @default.
• W70001411 cites W1966684193 @default.
• W70001411 cites W196864586 @default.
• W70001411 cites W1970625951 @default.
• W70001411 cites W1970928392 @default.
• W70001411 cites W1977779461 @default.
• W70001411 cites W1983376113 @default.
• W70001411 cites W2008081488 @default.
• W70001411 cites W2012898809 @default.
• W70001411 cites W2015999608 @default.
• W70001411 cites W2033125871 @default.
• W70001411 cites W2051867686 @default.
• W70001411 cites W2082167143 @default.
• W70001411 cites W2085585515 @default.
• W70001411 cites W2107739410 @default.
• W70001411 cites W2108494929 @default.
• W70001411 cites W2128635872 @default.
• W70001411 cites W2133100769 @default.
• W70001411 cites W2170526402 @default.
• W70001411 cites W2409661347 @default.
• W70001411 cites W2411932998 @default.
• W70001411 cites W2412572070 @default.
• W70001411 cites W52243265 @default.
• W70001411 cites W75288027 @default.
• W70001411 cites W80703649 @default.
• W70001411 cites W2503611873 @default.
• W70001411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11527942" @default.
• W70001411 hasPublicationYear "2001" @default.
• W70001411 type Work @default.
• W70001411 sameAs 70001411 @default.
• W70001411 citedByCount "61" @default.
• W70001411 countsByYear W700014112012 @default.
• W70001411 countsByYear W700014112013 @default.
• W70001411 countsByYear W700014112014 @default.
• W70001411 countsByYear W700014112015 @default.
• W70001411 countsByYear W700014112016 @default.
• W70001411 countsByYear W700014112017 @default.
• W70001411 countsByYear W700014112018 @default.
• W70001411 countsByYear W700014112019 @default.
• W70001411 countsByYear W700014112020 @default.
• W70001411 countsByYear W700014112021 @default.
• W70001411 countsByYear W700014112022 @default.
• W70001411 countsByYear W700014112023 @default.
• W70001411 crossrefType "journal-article" @default.
• W70001411 hasAuthorship W70001411A5000503977 @default.
• W70001411 hasAuthorship W70001411A5010748442 @default.
• W70001411 hasAuthorship W70001411A5031486216 @default.
• W70001411 hasAuthorship W70001411A5041065588 @default.
• W70001411 hasAuthorship W70001411A5049517490 @default.
• W70001411 hasConcept C118487528 @default.
• W70001411 hasConcept C119795356 @default.
• W70001411 hasConcept C142724271 @default.
• W70001411 hasConcept C153911025 @default.
• W70001411 hasConcept C181199279 @default.
• W70001411 hasConcept C185592680 @default.
• W70001411 hasConcept C189165786 @default.
• W70001411 hasConcept C2775838275 @default.
• W70001411 hasConcept C2776151105 @default.
• W70001411 hasConcept C2776882836 @default.
• W70001411 hasConcept C2778918178 @default.
• W70001411 hasConcept C28406088 @default.
• W70001411 hasConcept C55493867 @default.
• W70001411 hasConcept C71924100 @default.
• W70001411 hasConcept C86803240 @default.
• W70001411 hasConceptScore W70001411C118487528 @default.
• W70001411 hasConceptScore W70001411C119795356 @default.
• W70001411 hasConceptScore W70001411C142724271 @default.
• W70001411 hasConceptScore W70001411C153911025 @default.
• W70001411 hasConceptScore W70001411C181199279 @default.
• W70001411 hasConceptScore W70001411C185592680 @default.
• W70001411 hasConceptScore W70001411C189165786 @default.
• W70001411 hasConceptScore W70001411C2775838275 @default.
• W70001411 hasConceptScore W70001411C2776151105 @default.
• W70001411 hasConceptScore W70001411C2776882836 @default.
• W70001411 hasConceptScore W70001411C2778918178 @default.
• W70001411 hasConceptScore W70001411C28406088 @default.
• W70001411 hasConceptScore W70001411C55493867 @default.
• W70001411 hasConceptScore W70001411C71924100 @default.
• W70001411 hasConceptScore W70001411C86803240 @default.

• next