Matches in SemOpenAlex for { <https://semopenalex.org/work/W7010817> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W7010817 endingPage "311" @default.
- W7010817 startingPage "293" @default.
- W7010817 abstract "To make rapidly disintegrating tablets containing 8 mg ondansetron hydrochloride with suffi cient mechanical integrityas well as a pleasant taste, microcrystalline cellulose (MCC), lactose anhydrous, mannitol and croscarmellose wereformulated. Tablets were prepared by a direct compression method. Tablets properties such as tensile strength, disintegrationtime, wetting time and friability were determined. The two-factor spherical second order composite experimentaldesign was used for the preparation of preliminary batches and the desirability function was employed for theoptimization of preliminary batches. For preparation of the rapidly disintegrating tablets, simplex lattice design withconstraints on the proportion of excipients was utilized. In later design, tensile strength and disintegration time wereselected as dependent variables and concentration of microcrystalline cellulose, concentration of lactose anhydrous andconcentration of mannitol were selected as controlling factors. Mathematical equations and contour plots were usedto relate independent variables with tensile strength and disintegration time. Furthermore, the composite index which considers a positive or negative deviation from an ideal value was calculated for the optimization of the formulation.Contour plots of tensile strength and disintegration time were superimposed to fi nd out the optimized region at whichtablets with an acceptable crushing strength and disintegration time can be produced. The concept of similarity factorsf2 and Sd were used to prove similarity of dissolution in distilled water and simulated saliva (pH 6.8). Rapidly disintegratingtablets with durable structure and desirable taste could be prepared by selecting proper level of MCC, lactoseanhydrous, mannitol, croscarmellose and compression force." @default.
- W7010817 created "2016-06-24" @default.
- W7010817 creator A5022167741 @default.
- W7010817 creator A5039225054 @default.
- W7010817 creator A5081482551 @default.
- W7010817 creator A5087486634 @default.
- W7010817 date "2006-09-20" @default.
- W7010817 modified "2023-09-23" @default.
- W7010817 title "Preparación de comprimidos de desintegración rápida de clorhidrato de ondansetrón mediante el método de compresión directa" @default.
- W7010817 cites W1964264381 @default.
- W7010817 cites W1971194939 @default.
- W7010817 cites W1973317757 @default.
- W7010817 cites W1979611496 @default.
- W7010817 cites W1983521939 @default.
- W7010817 cites W1993786447 @default.
- W7010817 cites W1995676598 @default.
- W7010817 cites W2014815120 @default.
- W7010817 cites W2018205513 @default.
- W7010817 cites W2024345680 @default.
- W7010817 cites W2024910072 @default.
- W7010817 cites W2051076820 @default.
- W7010817 cites W2056735484 @default.
- W7010817 cites W2065444512 @default.
- W7010817 cites W2076369686 @default.
- W7010817 cites W2081007905 @default.
- W7010817 cites W2120497129 @default.
- W7010817 cites W2122958927 @default.
- W7010817 cites W2124147628 @default.
- W7010817 cites W2141216374 @default.
- W7010817 cites W2144893085 @default.
- W7010817 cites W2159269801 @default.
- W7010817 cites W2164861655 @default.
- W7010817 cites W2395988252 @default.
- W7010817 cites W2470021514 @default.
- W7010817 cites W1596461649 @default.
- W7010817 cites W2163794230 @default.
- W7010817 cites W2486980298 @default.
- W7010817 doi "https://doi.org/10.30827/ars.v47i3.5034" @default.
- W7010817 hasPublicationYear "2006" @default.
- W7010817 type Work @default.
- W7010817 sameAs 7010817 @default.
- W7010817 citedByCount "0" @default.
- W7010817 crossrefType "journal-article" @default.
- W7010817 hasAuthorship W7010817A5022167741 @default.
- W7010817 hasAuthorship W7010817A5039225054 @default.
- W7010817 hasAuthorship W7010817A5081482551 @default.
- W7010817 hasAuthorship W7010817A5087486634 @default.
- W7010817 hasConcept C112950240 @default.
- W7010817 hasConcept C159985019 @default.
- W7010817 hasConcept C178790620 @default.
- W7010817 hasConcept C185592680 @default.
- W7010817 hasConcept C187714232 @default.
- W7010817 hasConcept C191168616 @default.
- W7010817 hasConcept C192562407 @default.
- W7010817 hasConcept C2776035855 @default.
- W7010817 hasConcept C2777091354 @default.
- W7010817 hasConcept C2778724459 @default.
- W7010817 hasConcept C2779251873 @default.
- W7010817 hasConcept C2779351475 @default.
- W7010817 hasConcept C31903555 @default.
- W7010817 hasConcept C33923547 @default.
- W7010817 hasConcept C43617362 @default.
- W7010817 hasConcept C521977710 @default.
- W7010817 hasConceptScore W7010817C112950240 @default.
- W7010817 hasConceptScore W7010817C159985019 @default.
- W7010817 hasConceptScore W7010817C178790620 @default.
- W7010817 hasConceptScore W7010817C185592680 @default.
- W7010817 hasConceptScore W7010817C187714232 @default.
- W7010817 hasConceptScore W7010817C191168616 @default.
- W7010817 hasConceptScore W7010817C192562407 @default.
- W7010817 hasConceptScore W7010817C2776035855 @default.
- W7010817 hasConceptScore W7010817C2777091354 @default.
- W7010817 hasConceptScore W7010817C2778724459 @default.
- W7010817 hasConceptScore W7010817C2779251873 @default.
- W7010817 hasConceptScore W7010817C2779351475 @default.
- W7010817 hasConceptScore W7010817C31903555 @default.
- W7010817 hasConceptScore W7010817C33923547 @default.
- W7010817 hasConceptScore W7010817C43617362 @default.
- W7010817 hasConceptScore W7010817C521977710 @default.
- W7010817 hasIssue "3" @default.
- W7010817 hasLocation W70108171 @default.
- W7010817 hasOpenAccess W7010817 @default.
- W7010817 hasPrimaryLocation W70108171 @default.
- W7010817 hasVolume "47" @default.
- W7010817 isParatext "false" @default.
- W7010817 isRetracted "false" @default.
- W7010817 magId "7010817" @default.
- W7010817 workType "article" @default.