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- W70114997 abstract "Abstract Recombinant osteoprotegerin (OPG) promoted the adhesion of both primary polymorphonuclear neutrophils (PMN) and leukemic HL60 cells to endothelial cells. Leukocyte/endothelial cell adhesion was promoted by short (peak at 1 hour) pre-incubation of either endothelial cells or PMN with OPG, and the peak of pro-adhesive activity was observed in the same range of OPG concentrations detected in the sera of patients affected by cardiovascular diseases. While membrane RANKL and TRAIL, the cognate high-affinity ligands for OPG, were detected at significant levels on both PMN and HL60, they were not expressed on the surface of endothelial cells. However, pre-incubation of OPG with heparin abrogated its pro-adhesive activity, while pretreatment of endothelial cells with chondroitinase plus heparinases significantly decreased the pro-adhesive activity of OPG. Taken together, these findings suggest the involvement of both the ligand binding and the N-terminal heparin-binding domains of OPG in mediating its pro-adhesive activity. The relevance of these" @default.
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- W70114997 date "2013-01-01" @default.
- W70114997 modified "2023-09-23" @default.
- W70114997 title "in vitro and in vivo Osteoprotegerin increases leukocyte adhesion to endothelial cells both" @default.
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