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- W70165897 abstract "<h2>Summary</h2><h3>Background</h3> <i>Mycobacterium vaccae</i>, an envionmental saprophyte, has immunogenic properties that enhance the host immune response. Immunotherapy with <i>M vaccae</i>. has been suggested to shorten short-course antituberculosis chemotherapy. We tested the hypothesis that the addition of <i>M vaccae</i> to standard short-course antituberculosis chemotherapy would decrease the time to achieve a negative sputum culture. <h3>Methods</h3> Paients with newly diagnosed tuberculosis were randomly assigned an injection of saline (placebo) or <i>M vaccae</i> on day 8. All patients received antituberculosis chemotherapy with rifampicin, isoniazid, pyrazinamide, and ethambutol. Sputum samples were checked by microscopy and culture every week for the first 8 weeks and monthly until the end of chemotherapy at 6 months. The primary outcome was the time to a negative sputum culture in the first 8 weeks. Intentionto-treat analysis was used and time to sputum clearance was assessed by log-rank test and Cox's proportional-hazards regression. <h3>Findings</h3> 172 patients received <i>M vaccae</i> and 175 patients received placebo. At 8 weeks, 70 patients in the <i>M vaccae</i> group and 65 patients in the placebo group had a negative culture; there was no difference between groups in the time to a negative culture (p=0·83). There was no interaction between HIV status and treatment. <h3>Interpretation</h3> M vaccae immunotherapy has no benefit when added to standard antituberculosis chemotherapy." @default.
- W70165897 created "2016-06-24" @default.
- W70165897 date "1999-07-01" @default.
- W70165897 modified "2023-10-15" @default.
- W70165897 title "Immunotherapy with Mycobacterium vaccae in patients with newly diagnosed pulmonary tuberculosis: a randomised controlled trial" @default.
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- W70165897 doi "https://doi.org/10.1016/s0140-6736(98)10448-8" @default.
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