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- W70182529 abstract "ABSTRACT There is evidence that chronic opiate treatment affects levels, biosynthesis and/or release of endogenous opioid peptides. Thus, prolonged morphine treatment in rats inhibits synthesis of β-endorphin in the neurointermediate pituitary lobe via a mechanism involving a decrease in the activity of mRNA coding for the β-endorphin/ACTH precursor. This treatment, in contrast, increases concentrations of immunoreactive dynorphin - in parallel to vasopressin and oxytocin in this lobe. β-Endorphin levels in rat plasma after chronic morphine treatment are reduced in comparison to controls. There is no obvious relationship of these effects to the development of tolerance/dependence, but it seems possible that some protracted effects of opiate intake are related to such changes in endorphin metabolism." @default.
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- W70182529 date "1982-01-01" @default.
- W70182529 modified "2023-09-27" @default.
- W70182529 title "On the Role of Endorphins in Addiction" @default.
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- W70182529 doi "https://doi.org/10.1016/b978-0-08-028021-9.50011-3" @default.
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