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- W70208082 abstract "Genetically determined variation in the magnitude of inflammatory response may play a role in determining the risk of developing neonatal sepsis, as well as its outcome. To test the hypothesis that interleukin-6 (IL)-6 -174, IL-10 -1082 genetic polymorphisms are associated with the risk of sepsis and clinical outcomes in full-term neonates with blood stream infections (BSIs). A total of 54 full-term neonates with BSIs and 70 matched controls were included in this case/control study. DNA amplification using polymerase chain reaction with sequence-specific primers followed by NIaIII restriction enzyme digestion was done for detection of promoter single nucleotide polymorphism of IL-6 -174 G/C, amplification refractory mutation system-polymerase chain reaction assay was done for IL-10 -1082 G/A polymorphism in blood samples from all infants enrolled in the study. The IL-6 -174 and IL-10-1082 genotypes were not significantly different in neonates with BSIs compared to controls. Whereas, IL-6-174CC and IL-10-1082GG genotypes were associated with increased risk for mortality [Odds ratio (95% confidence intervals): 6.2 (1.3–28.4), P = 0.02 and 25.0 (2.0–74.3), P" @default.
- W70208082 created "2016-06-24" @default.
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- W70208082 date "2015-07-28" @default.
- W70208082 modified "2023-09-27" @default.
- W70208082 title "Genetic polymorphisms of IL-6-174 and IL-10-1082 in full term neonates with late onset blood stream infections" @default.
- W70208082 doi "https://doi.org/10.3233/jpi-2009-0203" @default.
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