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• W7023106 abstract "BACKGROUND The aim of this study was to analyze stable hypertrophied myocardial function and its response to inotropic maneuvers in rats submitted to renovascular hypertension for a 10-week period (RHT group, n=10). MATERIAL/METHODS Myocardial performance was studied in isolated left ventricle papillary muscles in isometric contraction under the following conditions: at postrest contraction of 30 seconds (PRC), at extracellular calcium (ECa2+) chloride concentration of 1.25 and 5.20 mM, and after beta-adrenergic stimulation with 10-6 M isoproterenol (ISOP). RESULTS The results were compared with normotensive Wistar controls rats (C group, n=10). In basal condition, resting tension, and contraction time (TPT) were greater, while relaxation time (RT50) tended to be longer in RHT than C group. PRC and ISOP promoted a similar change in muscle function response intensity (delta) in both groups. ECa2+ shift did not change TPT in the C group and decreased TPT in the RHT animals; delta was different between these groups. RT50 increased in C and decreased in RHT, both without statistical significance; however, delta was different. CONCLUSIONS These results suggest that hypertrophied myocardial dysfunction may be attributed to changes in intracellular calcium cycling." @default.
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• W7023106 date "2010-08-01" @default.
• W7023106 modified "2023-10-14" @default.
• W7023106 title "Hypertrophied myocardium is more dependent on extracellular calcium than the normal cardiac muscle." @default.
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