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- W70318623 abstract "The human carbonic anhydrase isoforms VA and VB (hCA VA/VB) are located in the mitochondria of specific cells. They supply bicarbonate ions to various physiological processes including lipogenesis, insulin secretion from pancreatic cells, ureagenesis, gluconeogenesis, and probably also regulation of neuronal transmission. Inhibitors of hCA VA/VB are considered as antiobesity drugs with a novel mechanism of action, and they might also be useful in the treatment of neuropathic pain. Activators might also have pharmaceutical potential, for example, as drugs against diabetes. Finally, this chapter will discuss the available structural information on the CA V isoforms and compare their sequences with other CA isoforms in the light of ligand–protein binding interactions." @default.
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- W70318623 date "2015-01-01" @default.
- W70318623 modified "2023-10-18" @default.
- W70318623 title "The Structure, Physiological Role, and Potential Medicinal Applications of Carbonic Anhydrase V" @default.
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- W70318623 doi "https://doi.org/10.1016/b978-0-444-63258-6.00007-x" @default.
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