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- W70405611 abstract "Infection by an attenuated replication-competent murine retrovirus (Friend leukemia virus-FLV4) ,but not other non-transforming retroviruses, stimulated rejection of transplantable thymomas (RL-cell line) and subsequent tumor immunity in syngeneic mouse recipients. FLV-infected RL-cells (RL-FLV) were unaltered in their in vitro growth, and grew progressively to kill sublethally irradiated animals and nude mice. Primary RL-FLV rejection was due to induction of increased natural killer (NK)-cell activity limited to peritoneal sites of tumor inoculation with a minor cytolytic macrophage population. Syngeneic mutant beige (NK-deficient) mice similarly rejected RL-FLV cells with increased peritoneal NK-cell activity and acquired immunity to the parental RL-tumor. While RL-FLV stimulated far greater peritoneal NK activity than did other tested retrovirus-infected RL-cells, the inherent susceptibility of these cells to lysis by normal NK cells was not altered by virus. RL-FLV induced NK effectors showed an indiscriminant lysis pattern that was independent of target cell type and retrovirus expression. Reconstitution studies revealed a necessary T-lymphocyte component for NK-cell stimulation by RL-FLV in mice, which may be lymphokine-mediated, but not" @default.
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- W70405611 date "1988-01-01" @default.
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- W70405611 title "Loss of Tumorigenicity Following in Vitro MuLV Infection is Associated with Induction of Peritoneal Natural Killer Cell Activity" @default.
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- W70405611 doi "https://doi.org/10.1007/978-1-4757-5421-6_17" @default.
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