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- W7041327 abstract "Biotin is required by animals and some microorganisms in extremely small amounts. Biotin is determinable in physiological amounts only by microbiological methods and it is synthesized by many microorganisms including those of the intestinal tract so that the production of a deficiency in humans and other animals is complicated, and it is covalently bound to apoenzymes rendering resolution of holoenzymes virtually impossible. The role of pimelic acid as a growth factor seems restricted to that of a precursor of biotin. Pimelic acid has been reported to be a vitamin for the larvae of the confused flour beetle, Tribolium confusum, but the activity recorded may be due to conversion to biotin by the flora of the intestinal tract. Pimelic acid fails to satisfy the biotin requirement of at least Lactobacillus casei, Lactobacillus arabinosus, biotin-requiring fungi, yeast, or Rhizobium trifolii, a very significant study of biotin biosynthesis in Achromobacter sp., which was isolated from the bovine rumen. The organism is rather anomalous because it fails to grow on media containing glucose as the main energy source, and it does not synthesize increased amounts of biotin when the medium is supplemented with pimelic acid." @default.
- W7041327 created "2016-06-24" @default.
- W7041327 creator A5054156016 @default.
- W7041327 creator A5064778502 @default.
- W7041327 date "1970-01-01" @default.
- W7041327 modified "2023-09-27" @default.
- W7041327 title "The Metabolism of Biotin and Analogues" @default.
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- W7041327 doi "https://doi.org/10.1016/b978-0-444-40871-6.50013-1" @default.
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