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- W70461271 abstract "Abstract Stability and membrane localization of Transforming growth factor-β (TGF-β) type I receptor (TβRI) is essential for controlling TGF-β signaling. TβRI is targeted for ubiquitination-mediated degradation by Smad7/Smurf2 complex. However, it is unclear whether polyubiquitin modified TβRI can be reversed. Here we performed a genome-wide gain of function screen and identified ubiquitin-specific protease (USP) 4 as a strong inducer of TGF-β signaling. Putative oncogenic USP4 was found to interact with TβRI as deubiquitinating enzyme thus maintains TβR1 levels at the plasma membrane. Depletion of USP4 mitigates TGF-β-induced breast cancer cell migration, epithelial to mesenchymal transition and metastasis. Importantly, Akt/Protein kinase B (PKB), which has been associated with poor prognosis in breast cancer, associates with and phosphorylates USP4. Akt mediated phosphorylation relocates USP4 to cytoplasm and membrane and is required for maintaining its protein stability. Moreover, Akt-induced breast cancer cell migration was inhibited by USP4 depletion and TβRI kinase inhibition. Our results identified USP4 as an important determinant for crosstalk between TGF-β and Akt, which provides new opportunities for cancer treatment." @default.
- W70461271 created "2016-06-24" @default.
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- W70461271 date "2012-01-19" @default.
- W70461271 modified "2023-10-02" @default.
- W70461271 title "USP4 is regulated by Akt phosphorylation and deubiquitylates TGF-beta type I receptor" @default.
- W70461271 doi "https://doi.org/10.1038/npre.2012.6804.1" @default.
- W70461271 hasPublicationYear "2012" @default.
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