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- W70487943 abstract "Cardiovascular complications are the main cause of morbidity and mortality among patients with CKD. It is common knowledge that in atherogenesis the disorders of calcium--phosphate metabolism count. The molecules of paramount importance are OPN and BMP-7, inhibiting calcification, and PDGF-BB, facilitating this process.to assess the concentrations of the above mentioned factors and their correlation with other markers of atherogenesis in children with CKD.OPN, PDGF-BB and BMP-7 plasma concentrations were assessed by ELISA in 18 patients with CKD (stage: I-IV) and in 12 patients from the control group. Ca-P parameters and the lipid profile were also estimated in both groups.OPN concentrations were comparable in both groups. PDGF-BB median values were lower (p < 0.05) and BMP-7 concentrations--higher in CKD patients than in the controls (p < 0.005). The PDGF-BB concentrations correlated negatively with OPN (R = -0.75, p < 0.001) and CRP (R = -0.71, p < 0.05) in CKD children. The negative correlation was also observed between OPN concentrations and hematocrit (R = -0.49, p < 0.04) and hemoglobin (R = -0.48, p < 0.04) values. In all patients the levels of Ca, P, alkaline phosphatase and PTH were within the normal range.The increase of BMP-7 concentrations and decrease of PDGF-BB values in children with CKD, coexisting with well controlled Ca-P metabolism parameters, may suggest early mobilization of mechanisms protecting against vascular calcification. These changes seem independent of dyslipidemia." @default.
- W70487943 created "2016-06-24" @default.
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- W70487943 date "2008-01-01" @default.
- W70487943 modified "2023-09-23" @default.
- W70487943 title "[Osteopontin (OPN), PDGF-BB (platelet-derived growth factor) and BMP-7 (bone morphogenetic protein) as markers of atherogenesis in children with chronic kidney disease (CKD) treated conservatively--preliminary results]." @default.
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