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• W70509926 abstract "Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidification. The aim of our study is to investigate whether IL-8 and pH levels in EBC of cystic fibrosis (CF) children with respiratory exacerbations change after antibiotic treatment. Lung function, IL-8 and pH EBC values were measured in fifteen CF children (mean age 11 years) with acute exacerbation before (T0) and after two weeks (T1) of antibiotic treatment. IL-8 and pH values were compared by paired t-test. A p<0.05 was considered significant. IL-8 EBC levels decreased after antibiotic treatment (TO 0.36±0.03pg/ml vs T1 0.28±0.03pg/ml; p=0.03) and pH values increased (TO 7.3610.09 vs T1 7.61±0.08; p=0.04). Results suggest possible application of EBC as a non-invasive tool to monitor efficacy of antibiotic treatment in CF patients." @default.
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• W70509926 date "2007-07-01" @default.
• W70509926 modified "2023-09-26" @default.
• W70509926 title "IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children" @default.
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• W70509926 doi "https://doi.org/10.1177/039463200702000305" @default.
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