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- W70608355 abstract "Publisher Summary This chapter discusses the metabolism of p-chlorophenylalanine (p-CP) and the molecular aspects of its action. Some of the monooxygenases get inhibited by DL-p-chlorophenylalanine in vitro and in vivo. The monooxygenases that are affected by administration of DL-p-CP are phenylalanine 4-hydroxylase and cerebral tryptophan 5-hydroxylase. It was postulated that the inactivation of these monooxygenases was primarily because of the incorporation of p-CP into the enzyme protein near or at the active site. Earlier studies indicated that that hepatic phenylalanine hydroxylase was markedly inhibited, and in the brain, the inhibition of hydroxylation of tryptophan became coincident with the increase of cerebral p-CP. Although this was confirmed, a quantitative difference was found with respect to the correlation between the extent of inhibition and the amount of p-CP present in the brain." @default.
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- W70608355 date "1973-01-01" @default.
- W70608355 modified "2023-09-30" @default.
- W70608355 title "METABOLISM OF p-CHLOROPHENYLALANINE AND THE MOLECULAR ASPECTS OF ITS ACTION" @default.
- W70608355 doi "https://doi.org/10.1016/b978-0-12-078150-8.50010-4" @default.
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