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- W7062075 endingPage "21" @default.
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- W7062075 abstract "<h3>Background:</h3> Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological processes and whose dysfunction may contribute to several different diseases, such as neurodegenerative diseases, circadian and mood disorders, insomnia, type 2 diabetes and pain. Melatonin is synthesized by the pineal gland during the night and acts through 2 G-protein coupled receptors (GPCRs), MT<sub>1</sub> (MEL1a) and MT<sub>2</sub> (MEL1b). Although a bulk of research has examined the physiopathological effects of MLT, few studies have investigated the selective role played by MT<sub>1</sub> and MT<sub>2</sub> receptors. Here we have reviewed current knowledge about the implications of MT<sub>2</sub> receptors in brain functions. <h3>Methods:</h3> We searched PubMed, Web of Science, Scopus, Google Scholar and articles reference lists for studies on MT<sub>2</sub> receptor ligands in sleep, anxiety, neuropsychiatric diseases and psychopharmacology, including genetic studies on the <i>MTNR1B</i> gene, which encodes the melatonin MT<sub>2</sub> receptor. <h3>Results:</h3> These studies demonstrate that MT<sub>2</sub> receptors are involved in the pathophysiology and pharmacology of sleep disorders, anxiety, depression, Alzheimer disease and pain and that selective MT<sub>2</sub> receptor agonists show hypnotic and anxiolytic properties. <h3>Limitations:</h3> Studies examining the role of MT<sub>2</sub> receptors in psychopharmacology are still limited. <h3>Conclusion:</h3> The development of novel selective MT<sub>2</sub> receptor ligands, together with further preclinical in vivo studies, may clarify the role of this receptor in brain function and psychopharmacology. The superfamily of GPCRs has proven to be among the most successful drug targets and, consequently, MT<sub>2</sub> receptors have great potential for pioneer drug discovery in the treatment of mental diseases for which limited therapeutic targets are currently available." @default.
- W7062075 created "2016-06-24" @default.
- W7062075 creator A5010580951 @default.
- W7062075 creator A5018646315 @default.
- W7062075 date "2014-01-01" @default.
- W7062075 modified "2023-10-01" @default.
- W7062075 title "Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology" @default.
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