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- W70622507 abstract "This chapter discusses the influence of macrophage Ir gene function on T & B lymphocytes. Macrophages (MØ) are the initial cells to take up antigens prior to their presentation to immunologically specific T lymphocytes. MØ do not have to be from immune animals to perform this function. The in vitro studies have revealed that immune lymphocytes do form stable antigen specific clusters around macrophages. These clusters are an essential prerequisite for subsequent antigen-specific T cell proliferation suggesting that physical interactions between MØ and lymphocytes are required in an immune response. It is postulated that the site of expression of the histocompatibility-linked Ir genes may be at the level of the MØ rather than in the responding T cell. According to this theory, nonresponder macrophages would lack the I-region product needed to process or present the genetically controlled antigen. The chapter reviews the data that supports or refutes this hypothesis. It focuses on the influence of the MØ Ir gene function on T cells activation and also presents recent studies on the role of MØ and T cells in antibody secretion by B cells." @default.
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- W70622507 date "1979-01-01" @default.
- W70622507 modified "2023-09-25" @default.
- W70622507 title "THE INFLUENCE OF MACROPHAGE IR GENE FUNCTION ON T & B LYMPHOCYTES" @default.
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- W70622507 doi "https://doi.org/10.1016/b978-0-12-569650-0.50050-4" @default.
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