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- W7069306 abstract "The three-dimensional structure of the salvage pathway enzyme purine nucleoside phosphorylase (EC 2.4.2.1) as determined by X-ray crystallography has been used to design inhibitors of the enzyme. The design process is an iterative one utilizing X-ray crystallographic analysis, interactive computer graphics, Monte Carlo-based conformational searching, and energy minimization. The proposed compounds were synthesized, their IC50 values for inhibition of the enzyme determined, and the structures of their complexes with PNP analyzed by X-ray analysis. This procedure has led to the discovery of the most potent membrane-permeable competitive inhibitors of this enzyme thus far reported." @default.
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- W7069306 date "1993-02-01" @default.
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- W7069306 title "Structure-based drug design: inhibitors of purine nucleoside phosphorylase." @default.
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