Matches in SemOpenAlex for { <https://semopenalex.org/work/W70756783> ?p ?o ?g. }
- W70756783 endingPage "399" @default.
- W70756783 startingPage "375" @default.
- W70756783 abstract "Morphogenesis is the developmental process by which tissues and organs acquire the shape that is critical to their function. Here, we review recent advances in our understanding of the mechanisms that drive morphogenesis in the developing eye. These investigations have shown that regulation of the actin cytoskeleton is central to shaping the presumptive lens and retinal epithelia that are the major components of the eye. Regulation of the actin cytoskeleton is mediated by Rho family GTPases, by signaling pathways and indirectly, by transcription factors that govern the expression of critical genes. Changes in the actin cytoskeleton can shape cells through the generation of filopodia (that, in the eye, connect adjacent epithelia) or through apical constriction, a process that produces a wedge-shaped cell. We have also learned that one tissue can influence the shape of an adjacent one, probably by direct force transmission, in a process we term inductive morphogenesis. Though these mechanisms of morphogenesis have been identified using the eye as a model system, they are likely to apply broadly where epithelia influence the shape of organs during development." @default.
- W70756783 created "2016-06-24" @default.
- W70756783 creator A5012864578 @default.
- W70756783 creator A5024272087 @default.
- W70756783 creator A5031330923 @default.
- W70756783 creator A5036883465 @default.
- W70756783 date "2015-01-01" @default.
- W70756783 modified "2023-10-14" @default.
- W70756783 title "Epithelial Morphogenesis" @default.
- W70756783 cites W1483496013 @default.
- W70756783 cites W1498435062 @default.
- W70756783 cites W1524475817 @default.
- W70756783 cites W1604453774 @default.
- W70756783 cites W1951134872 @default.
- W70756783 cites W1967124592 @default.
- W70756783 cites W1967307099 @default.
- W70756783 cites W1968680922 @default.
- W70756783 cites W1968826282 @default.
- W70756783 cites W1969200465 @default.
- W70756783 cites W1977831337 @default.
- W70756783 cites W1978529327 @default.
- W70756783 cites W1979346765 @default.
- W70756783 cites W1979451137 @default.
- W70756783 cites W1980985436 @default.
- W70756783 cites W1983328516 @default.
- W70756783 cites W1984387240 @default.
- W70756783 cites W1984491329 @default.
- W70756783 cites W1985251038 @default.
- W70756783 cites W1986163885 @default.
- W70756783 cites W1986597110 @default.
- W70756783 cites W1987590880 @default.
- W70756783 cites W1987817703 @default.
- W70756783 cites W1988256357 @default.
- W70756783 cites W1992660304 @default.
- W70756783 cites W1994525772 @default.
- W70756783 cites W1994936546 @default.
- W70756783 cites W1996619733 @default.
- W70756783 cites W1997140988 @default.
- W70756783 cites W1998719065 @default.
- W70756783 cites W1999810994 @default.
- W70756783 cites W2000952815 @default.
- W70756783 cites W2003473548 @default.
- W70756783 cites W2010392821 @default.
- W70756783 cites W2013166782 @default.
- W70756783 cites W2014913899 @default.
- W70756783 cites W2015603050 @default.
- W70756783 cites W2015619728 @default.
- W70756783 cites W2016450222 @default.
- W70756783 cites W2019800582 @default.
- W70756783 cites W2021856025 @default.
- W70756783 cites W2024330189 @default.
- W70756783 cites W2024342524 @default.
- W70756783 cites W2024527973 @default.
- W70756783 cites W2025238312 @default.
- W70756783 cites W2027810531 @default.
- W70756783 cites W2028542401 @default.
- W70756783 cites W2031489662 @default.
- W70756783 cites W2034341872 @default.
- W70756783 cites W2036145275 @default.
- W70756783 cites W2039731137 @default.
- W70756783 cites W2042639779 @default.
- W70756783 cites W2043838659 @default.
- W70756783 cites W2047284392 @default.
- W70756783 cites W2047580046 @default.
- W70756783 cites W2048305477 @default.
- W70756783 cites W2048740701 @default.
- W70756783 cites W2053928527 @default.
- W70756783 cites W2056210035 @default.
- W70756783 cites W2057538818 @default.
- W70756783 cites W2059055489 @default.
- W70756783 cites W2060990332 @default.
- W70756783 cites W2062325757 @default.
- W70756783 cites W2064887578 @default.
- W70756783 cites W2067917704 @default.
- W70756783 cites W2068486863 @default.
- W70756783 cites W2070263067 @default.
- W70756783 cites W2070502859 @default.
- W70756783 cites W2071199281 @default.
- W70756783 cites W2072837740 @default.
- W70756783 cites W2073006837 @default.
- W70756783 cites W2073947789 @default.
- W70756783 cites W2074314696 @default.
- W70756783 cites W2074867744 @default.
- W70756783 cites W2077080652 @default.
- W70756783 cites W2078909919 @default.
- W70756783 cites W2084219861 @default.
- W70756783 cites W2084321497 @default.
- W70756783 cites W2089407911 @default.
- W70756783 cites W2092245168 @default.
- W70756783 cites W2097458810 @default.
- W70756783 cites W2098179044 @default.
- W70756783 cites W2099954462 @default.
- W70756783 cites W2102312968 @default.
- W70756783 cites W2104295566 @default.
- W70756783 cites W2105746559 @default.
- W70756783 cites W2110881251 @default.
- W70756783 cites W2111904994 @default.
- W70756783 cites W2113579248 @default.