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- W7077060 abstract "Fluoroatipamezole, an analogue of the {alpha}2 adrenoreceptor antagonist atipamezole, is a potential candidate for mapping adrenergic innervation in the human brain with PET. As a nucleophilic route failed, F-18-labelling was achieved by electrophillic fluorination of a stannylated precursor. The fluorinated compound was injected into rats, and the uptake in various organs was studied as a function of time (30, 60, 120 min). Also autoradiographic images of microtome slices of rat brain were recorded and analysed. The synthesis yield was {approximately} 3% (decay-corrected) as calculated from the F-18-fluoride produced. The specific radioactivity was {approximately} 350 mCi/{mu}mole at EOS." @default.
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- W7077060 date "1996-05-01" @default.
- W7077060 modified "2023-09-23" @default.
- W7077060 title "Synthesis of [F-18]fluoroatipamezole. Biodistribution in rats" @default.
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