FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W70790581> ?p ?o ?g. }

• W70790581 endingPage "9" @default.
• W70790581 startingPage "1143" @default.
• W70790581 abstract "Pulmonary Langerhans cell granulomatosis (LCG), also called histiocytosis X, is a disorder of unknown etiology characterized by the presence of destructive granulomas containing numerous Langerhans cells (LCs). The process may be localized or multifocal, and it remains unclear whether the same pathogenic mechanism is involved in all forms of the disease. It is often assumed that the massive accumulation of LCs at the sites of the lesions results from the abnormal proliferation of these cells, although it has been suggested that LCG in adults, at least in the lung, could be a reactive disorder initiated by activated LCs. Little is known, however, concerning the mechanisms responsible for the accumulation of large numbers of LCs in the course of the disease, and the relative contribution of recruitment and local proliferation of these cells remains to be established. To investigate this question, the proportion of replicating LCs was evaluated in biopsied granulomas from patients with localized or diffuse form of LCG by means of several histopathological techniques currently used in assessment of cell proliferation. The findings demonstrate that, except for proliferating cell nuclear antigen (PCNA), all parameters measured are low in all forms of the disease. They are similar to those of renewing epithelial cells and clearly less than those of neoplastic cells. These data strongly suggest that LCs in LCG granulomas are not a rapidly dividing cell population and that local LC replication makes only a minimal contribution to granuloma maintenance. Caution appears to be necessary in the use of PCNA as a marker of growth fraction." @default.
• W70790581 created "2016-06-24" @default.
• W70790581 creator A5020725877 @default.
• W70790581 creator A5029187559 @default.
• W70790581 creator A5034466475 @default.
• W70790581 creator A5054720796 @default.
• W70790581 creator A5071664002 @default.
• W70790581 creator A5071911978 @default.
• W70790581 creator A5081130249 @default.
• W70790581 creator A5087449110 @default.
• W70790581 date "1998-05-01" @default.
• W70790581 modified "2023-09-23" @default.
• W70790581 title "Langerhans cells in Langerhans cell granulomatosis are not actively proliferating cells." @default.
• W70790581 cites W124276810 @default.
• W70790581 cites W179293865 @default.
• W70790581 cites W1964118772 @default.
• W70790581 cites W1980222829 @default.
• W70790581 cites W1983253416 @default.
• W70790581 cites W2006626786 @default.
• W70790581 cites W200914752 @default.
• W70790581 cites W2014183131 @default.
• W70790581 cites W2019546595 @default.
• W70790581 cites W2031186698 @default.
• W70790581 cites W2039685885 @default.
• W70790581 cites W2041361019 @default.
• W70790581 cites W2046448747 @default.
• W70790581 cites W2051972386 @default.
• W70790581 cites W2052039805 @default.
• W70790581 cites W2053041006 @default.
• W70790581 cites W2053717292 @default.
• W70790581 cites W2060597629 @default.
• W70790581 cites W2060937867 @default.
• W70790581 cites W2068752764 @default.
• W70790581 cites W2072448326 @default.
• W70790581 cites W2072663865 @default.
• W70790581 cites W2085153622 @default.
• W70790581 cites W2103555767 @default.
• W70790581 cites W2105694198 @default.
• W70790581 cites W2110172112 @default.
• W70790581 cites W2124617998 @default.
• W70790581 cites W2130126671 @default.
• W70790581 cites W2163864783 @default.
• W70790581 cites W2325716909 @default.
• W70790581 cites W2419415001 @default.
• W70790581 cites W2460875886 @default.
• W70790581 cites W260353900 @default.
• W70790581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1858573" @default.
• W70790581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9588881" @default.
• W70790581 hasPublicationYear "1998" @default.
• W70790581 type Work @default.
• W70790581 sameAs 70790581 @default.
• W70790581 citedByCount "18" @default.
• W70790581 countsByYear W707905812012 @default.
• W70790581 countsByYear W707905812013 @default.
• W70790581 countsByYear W707905812017 @default.
• W70790581 countsByYear W707905812020 @default.
• W70790581 crossrefType "journal-article" @default.
• W70790581 hasAuthorship W70790581A5020725877 @default.
• W70790581 hasAuthorship W70790581A5029187559 @default.
• W70790581 hasAuthorship W70790581A5034466475 @default.
• W70790581 hasAuthorship W70790581A5054720796 @default.
• W70790581 hasAuthorship W70790581A5071664002 @default.
• W70790581 hasAuthorship W70790581A5071911978 @default.
• W70790581 hasAuthorship W70790581A5081130249 @default.
• W70790581 hasAuthorship W70790581A5087449110 @default.
• W70790581 hasConcept C126322002 @default.
• W70790581 hasConcept C142724271 @default.
• W70790581 hasConcept C147483822 @default.
• W70790581 hasConcept C1491633281 @default.
• W70790581 hasConcept C203014093 @default.
• W70790581 hasConcept C204232928 @default.
• W70790581 hasConcept C2777484599 @default.
• W70790581 hasConcept C2777714996 @default.
• W70790581 hasConcept C2778379841 @default.
• W70790581 hasConcept C2779134260 @default.
• W70790581 hasConcept C2780174970 @default.
• W70790581 hasConcept C2908647359 @default.
• W70790581 hasConcept C34688535 @default.
• W70790581 hasConcept C54355233 @default.
• W70790581 hasConcept C62112901 @default.
• W70790581 hasConcept C71924100 @default.
• W70790581 hasConcept C86803240 @default.
• W70790581 hasConcept C99454951 @default.
• W70790581 hasConceptScore W70790581C126322002 @default.
• W70790581 hasConceptScore W70790581C142724271 @default.
• W70790581 hasConceptScore W70790581C147483822 @default.
• W70790581 hasConceptScore W70790581C1491633281 @default.
• W70790581 hasConceptScore W70790581C203014093 @default.
• W70790581 hasConceptScore W70790581C204232928 @default.
• W70790581 hasConceptScore W70790581C2777484599 @default.
• W70790581 hasConceptScore W70790581C2777714996 @default.
• W70790581 hasConceptScore W70790581C2778379841 @default.
• W70790581 hasConceptScore W70790581C2779134260 @default.
• W70790581 hasConceptScore W70790581C2780174970 @default.
• W70790581 hasConceptScore W70790581C2908647359 @default.
• W70790581 hasConceptScore W70790581C34688535 @default.
• W70790581 hasConceptScore W70790581C54355233 @default.
• W70790581 hasConceptScore W70790581C62112901 @default.

• next