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- W70822257 abstract "Data support the usefulness of tissue culture in isolation and preservation of islets prior to transplantation. Rodent islet viability in culture was demonstrated histologically and by functional analyses of hormone production. For reasons that remain to be defined, acinar cells disappeared rapidly in tissue culture, yielding an implant preparation relatively rich in islets and devoid of pancreatic exocrine elements. Isografts of cultured and noncultured islets were well tolerated intraperitoneally and intramuscularly; and prompt and lasting reversal of short- and long-standing experimental diabetes was observed regularly. In vitro studies of rodent islet viability after immunosuppressive treatment of donors or islet cultures showed insulin production comparable to that of control experiments, suggesting that immunologic modification of donors or islets might be feasible in eventual human islet allotransplantation." @default.
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- W70822257 date "1979-03-01" @default.
- W70822257 modified "2023-09-27" @default.
- W70822257 title "Organ culture studies for pancreatic islet transplantation. [Rats, x radiation]" @default.
- W70822257 hasPublicationYear "1979" @default.
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