Matches in SemOpenAlex for { <https://semopenalex.org/work/W70934718> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W70934718 endingPage "223" @default.
- W70934718 startingPage "213" @default.
- W70934718 abstract "The optimal regimen for stimulating a secretory IgA response in the intestine has yet to be determined. It is well known that parenteral administration of antigen will result in the formation of a systemic immune response directed to specific determinants on that antigen. Depending on the characteristics of the antigen, its dose, and the genetic capabilities of the animal, a humoral and/or cellular immune responses will result. While similar mechanisms must occur to stimulate immunity to antigens which are present in mucosal surfaces, including the gastrointestinal tract, less is known about the specific form or dose of antigens which would best elicit the production of immunity in the mucosa itself. It has been known for over a century that oral administration of antigens can elicit protection to some enteric infections. The discovery that IgA is the main antibody on mucosal surfaces provided the key for beginning definitive work to understand the biology of the mucosal immune system (Tomasi et al. 1965). While many tissues (bronchial mucosa, mammary glands, conjunctiva, genitourinary tract, biliary tract, etc.) are involved with the mucosal immune response, the gastrointestinal tract is overwhelmingly the major site of antigenic stimulation and immune response for secretory IgA (Brandtzaeg 1985). Recent studies indicate that a combination of parenteral and oral administration of antigens may enhance the initial secretory IgA response to Shigella flexneri (Keren et al. 1988). This review explores the mechanism for stimulation of the secretory IgA memory response to shigella lipopolysaccharide (LPS) and to Shiga toxin." @default.
- W70934718 created "2016-06-24" @default.
- W70934718 creator A5020581821 @default.
- W70934718 creator A5035368655 @default.
- W70934718 creator A5043828812 @default.
- W70934718 creator A5072459634 @default.
- W70934718 creator A5079140534 @default.
- W70934718 date "1989-01-01" @default.
- W70934718 modified "2023-09-25" @default.
- W70934718 title "The Enteric Immune Response to Shigella Antigens" @default.
- W70934718 cites W1594826119 @default.
- W70934718 cites W1632564255 @default.
- W70934718 cites W1722244586 @default.
- W70934718 cites W1765938992 @default.
- W70934718 cites W1838985993 @default.
- W70934718 cites W1850017326 @default.
- W70934718 cites W1936762042 @default.
- W70934718 cites W1943862102 @default.
- W70934718 cites W1980073902 @default.
- W70934718 cites W2007518207 @default.
- W70934718 cites W2098216740 @default.
- W70934718 cites W2118067399 @default.
- W70934718 cites W2151097964 @default.
- W70934718 cites W2164181086 @default.
- W70934718 cites W2331263279 @default.
- W70934718 cites W2419024389 @default.
- W70934718 cites W2419255276 @default.
- W70934718 cites W2420571355 @default.
- W70934718 doi "https://doi.org/10.1007/978-3-642-74529-4_23" @default.
- W70934718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2659270" @default.
- W70934718 hasPublicationYear "1989" @default.
- W70934718 type Work @default.
- W70934718 sameAs 70934718 @default.
- W70934718 citedByCount "7" @default.
- W70934718 countsByYear W709347182012 @default.
- W70934718 countsByYear W709347182021 @default.
- W70934718 crossrefType "book-chapter" @default.
- W70934718 hasAuthorship W70934718A5020581821 @default.
- W70934718 hasAuthorship W70934718A5035368655 @default.
- W70934718 hasAuthorship W70934718A5043828812 @default.
- W70934718 hasAuthorship W70934718A5072459634 @default.
- W70934718 hasAuthorship W70934718A5079140534 @default.
- W70934718 hasConcept C104317684 @default.
- W70934718 hasConcept C147483822 @default.
- W70934718 hasConcept C203014093 @default.
- W70934718 hasConcept C2776986154 @default.
- W70934718 hasConcept C2780512811 @default.
- W70934718 hasConcept C2781065037 @default.
- W70934718 hasConcept C2781217973 @default.
- W70934718 hasConcept C523546767 @default.
- W70934718 hasConcept C54355233 @default.
- W70934718 hasConcept C547475151 @default.
- W70934718 hasConcept C55493867 @default.
- W70934718 hasConcept C86803240 @default.
- W70934718 hasConcept C8891405 @default.
- W70934718 hasConcept C89423630 @default.
- W70934718 hasConceptScore W70934718C104317684 @default.
- W70934718 hasConceptScore W70934718C147483822 @default.
- W70934718 hasConceptScore W70934718C203014093 @default.
- W70934718 hasConceptScore W70934718C2776986154 @default.
- W70934718 hasConceptScore W70934718C2780512811 @default.
- W70934718 hasConceptScore W70934718C2781065037 @default.
- W70934718 hasConceptScore W70934718C2781217973 @default.
- W70934718 hasConceptScore W70934718C523546767 @default.
- W70934718 hasConceptScore W70934718C54355233 @default.
- W70934718 hasConceptScore W70934718C547475151 @default.
- W70934718 hasConceptScore W70934718C55493867 @default.
- W70934718 hasConceptScore W70934718C86803240 @default.
- W70934718 hasConceptScore W70934718C8891405 @default.
- W70934718 hasConceptScore W70934718C89423630 @default.
- W70934718 hasLocation W709347181 @default.
- W70934718 hasLocation W709347182 @default.
- W70934718 hasOpenAccess W70934718 @default.
- W70934718 hasPrimaryLocation W709347181 @default.
- W70934718 hasRelatedWork W1936804077 @default.
- W70934718 hasRelatedWork W1995739394 @default.
- W70934718 hasRelatedWork W2007197096 @default.
- W70934718 hasRelatedWork W2028556579 @default.
- W70934718 hasRelatedWork W2087311809 @default.
- W70934718 hasRelatedWork W2114811932 @default.
- W70934718 hasRelatedWork W2169374130 @default.
- W70934718 hasRelatedWork W2170644493 @default.
- W70934718 hasRelatedWork W4280596063 @default.
- W70934718 hasRelatedWork W70934718 @default.
- W70934718 isParatext "false" @default.
- W70934718 isRetracted "false" @default.
- W70934718 magId "70934718" @default.
- W70934718 workType "book-chapter" @default.