FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W70984977> ?p ?o ?g. }

• W70984977 abstract "The wide use of paclitaxel and docetaxel in NSCLC clinical treatment makes it necessary to find biomarkers for identifying patients who can benefit from paclitaxel or docetaxel. In present study, NCI-H460, a NSCLC cell line with different sensitivity to paclitaxel and docetaxel, was applied to DNA microarray expression profiling analysis at different time points of lower dose treatment with paclitaxel or docetaxel. And the complex signaling pathways regulating the drug response were identified, and several novel sensitivity-realted markers were biocomputated.The dynamic changes of responding genes showed that paclitaxel effect is acute but that of docetaxel is durable at least for 48 hours in NCI-H460 cells. Functional annotation of the genes with altered expression showed that genes/pathways responding to these two drugs were dramatically different. Gene expression changes induced by paclitaxel treatment were mainly enriched in actin cytoskeleton (ACTC1, MYL2 and MYH2), tyrosine-protein kinases (ERRB4, KIT and TIE1) and focal adhesion pathway (MYL2, IGF1 and FLT1), while the expression alterations responding to docetaxel were highly co-related to cell surface receptor linked signal transduction (SHH, DRD5 and ADM2), cytokine-cytokine receptor interaction (IL1A and IL6) and cell cycle regulation (CCNB1, CCNE2 and PCNA). Moreover, we also confirmed some different expression patterns with real time PCR. Our study will provide the potential biomarkers for paclitaxel and docetaxel-selection therapy in clinical application." @default.
• W70984977 created "2016-06-24" @default.
• W70984977 creator A5017276174 @default.
• W70984977 creator A5044320909 @default.
• W70984977 creator A5061184494 @default.
• W70984977 creator A5069680097 @default.
• W70984977 creator A5075041544 @default.
• W70984977 creator A5078526337 @default.
• W70984977 creator A5080395436 @default.
• W70984977 creator A5086632320 @default.
• W70984977 date "2013-01-01" @default.
• W70984977 modified "2023-09-26" @default.
• W70984977 title "DNA microarray reveals different pathways responding to paclitaxel and docetaxel in non-small cell lung cancer cell line." @default.
• W70984977 cites W1935885922 @default.
• W70984977 cites W1976422592 @default.
• W70984977 cites W1981765582 @default.
• W70984977 cites W1990302968 @default.
• W70984977 cites W1992867510 @default.
• W70984977 cites W1994450611 @default.
• W70984977 cites W1999527502 @default.
• W70984977 cites W2010720008 @default.
• W70984977 cites W2071496368 @default.
• W70984977 cites W2074459357 @default.
• W70984977 cites W2084087358 @default.
• W70984977 cites W2092931003 @default.
• W70984977 cites W2095628944 @default.
• W70984977 cites W2099801548 @default.
• W70984977 cites W2106042158 @default.
• W70984977 cites W2107370345 @default.
• W70984977 cites W2110110495 @default.
• W70984977 cites W2110355689 @default.
• W70984977 cites W2110418441 @default.
• W70984977 cites W2112443004 @default.
• W70984977 cites W2115852285 @default.
• W70984977 cites W2126427337 @default.
• W70984977 cites W2127405377 @default.
• W70984977 cites W2128082578 @default.
• W70984977 cites W2145004989 @default.
• W70984977 cites W2157795344 @default.
• W70984977 cites W2166825080 @default.
• W70984977 cites W3145077989 @default.
• W70984977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3726969" @default.
• W70984977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23923072" @default.
• W70984977 hasPublicationYear "2013" @default.
• W70984977 type Work @default.
• W70984977 sameAs 70984977 @default.
• W70984977 citedByCount "10" @default.
• W70984977 countsByYear W709849772015 @default.
• W70984977 countsByYear W709849772017 @default.
• W70984977 countsByYear W709849772019 @default.
• W70984977 countsByYear W709849772021 @default.
• W70984977 countsByYear W709849772022 @default.
• W70984977 countsByYear W709849772023 @default.
• W70984977 crossrefType "journal-article" @default.
• W70984977 hasAuthorship W70984977A5017276174 @default.
• W70984977 hasAuthorship W70984977A5044320909 @default.
• W70984977 hasAuthorship W70984977A5061184494 @default.
• W70984977 hasAuthorship W70984977A5069680097 @default.
• W70984977 hasAuthorship W70984977A5075041544 @default.
• W70984977 hasAuthorship W70984977A5078526337 @default.
• W70984977 hasAuthorship W70984977A5080395436 @default.
• W70984977 hasAuthorship W70984977A5086632320 @default.
• W70984977 hasConcept C121608353 @default.
• W70984977 hasConcept C2777292972 @default.
• W70984977 hasConcept C2781190966 @default.
• W70984977 hasConcept C502942594 @default.
• W70984977 hasConcept C54355233 @default.
• W70984977 hasConcept C62478195 @default.
• W70984977 hasConcept C86803240 @default.
• W70984977 hasConcept C95444343 @default.
• W70984977 hasConceptScore W70984977C121608353 @default.
• W70984977 hasConceptScore W70984977C2777292972 @default.
• W70984977 hasConceptScore W70984977C2781190966 @default.
• W70984977 hasConceptScore W70984977C502942594 @default.
• W70984977 hasConceptScore W70984977C54355233 @default.
• W70984977 hasConceptScore W70984977C62478195 @default.
• W70984977 hasConceptScore W70984977C86803240 @default.
• W70984977 hasConceptScore W70984977C95444343 @default.
• W70984977 hasLocation W709849771 @default.
• W70984977 hasOpenAccess W70984977 @default.
• W70984977 hasPrimaryLocation W709849771 @default.
• W70984977 hasRelatedWork W1937166149 @default.
• W70984977 hasRelatedWork W1983937766 @default.
• W70984977 hasRelatedWork W2006968024 @default.
• W70984977 hasRelatedWork W2060641409 @default.
• W70984977 hasRelatedWork W2064281184 @default.
• W70984977 hasRelatedWork W2068852196 @default.
• W70984977 hasRelatedWork W2076718204 @default.
• W70984977 hasRelatedWork W2106761385 @default.
• W70984977 hasRelatedWork W2118460329 @default.
• W70984977 hasRelatedWork W2123555204 @default.
• W70984977 hasRelatedWork W2126493600 @default.
• W70984977 hasRelatedWork W2148899154 @default.
• W70984977 hasRelatedWork W2174923701 @default.
• W70984977 hasRelatedWork W2255847230 @default.
• W70984977 hasRelatedWork W2378194605 @default.
• W70984977 hasRelatedWork W2402449173 @default.
• W70984977 hasRelatedWork W2541844791 @default.
• W70984977 hasRelatedWork W2556279201 @default.
• W70984977 hasRelatedWork W3086738709 @default.

• next