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- W71014362 abstract "Mitochondria are major sources of reactive oxygen species (ROS) in cells, and they have been proposed to have an important role in cellular ageing. Recent evidence suggests that these organelles play a causal role in telomere-dependent senescence of human cells in culture. However, the relation between mitochondrial ROS production and replicative senescence might be more complicated than just simple cause and effect, because mitochondrial dysfunction has been shown to induce a variety of genes involved in nuclear-mitochondrial cross talk. Evidence suggests that this retrograde response might have an important, yet still relatively unexplored role in cell ageing, affecting mitochondrial function, ROS production, and, consequently, the life span of cells." @default.
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- W71014362 date "2008-01-01" @default.
- W71014362 modified "2023-09-23" @default.
- W71014362 title "Retrograde Response, Oxidative Stress, and Cellular Senescence" @default.
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- W71014362 doi "https://doi.org/10.1007/978-1-59745-420-9_3" @default.
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