Matches in SemOpenAlex for { <https://semopenalex.org/work/W71051318> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W71051318 endingPage "6" @default.
- W71051318 startingPage "1100" @default.
- W71051318 abstract "To determine the kinetics of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in serum and aqueous humor of rats with different susceptibilities to endotoxin-induced uveitis (EIU), after footpad injection of lipopolysaccharide (LPS).Samples were collected from EIU-susceptible Lewis rats and EIU-resistant Brown Norway (BN) rats for up to 72 hours after LPS injection. Specific bioassays were used to measure TNF and IL-6 activity. Northern blot analysis was used to assess intraocular IL-6 mRNA expression.High levels of TNF and IL-6 were detected in serum of both rat strains early after LPS injection. A second rise in serum TNF was observed at 18 to 20 hours in Lewis rats only. In aqueous humor of Lewis rats, high levels of TNF and IL-6 were observed early after LPS injection (2 to 8 hours) and concomitant with maximal uveitis (18 to 24 hours). Low levels of TNF and IL-6 were found in aqueous humor of BN rats. Ocular IL-6 mRNA was detected at the same time as IL-6 activity was measured in aqueous humor.The results of this study indicate that both TNF and IL-6 may play a role in the pathogenesis of EIU. The early release of TNF in aqueous humor during EIU suggests that this cytokine may serve as an initial mediator of intraocular inflammation. Furthermore, Northern blot analysis indicates that IL-6 is produced locally during EIU." @default.
- W71051318 created "2016-06-24" @default.
- W71051318 creator A5005016013 @default.
- W71051318 creator A5041086406 @default.
- W71051318 creator A5060911670 @default.
- W71051318 creator A5069416813 @default.
- W71051318 creator A5081413476 @default.
- W71051318 date "1994-03-01" @default.
- W71051318 modified "2023-10-03" @default.
- W71051318 title "Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat." @default.
- W71051318 cites W1521642954 @default.
- W71051318 cites W1567817045 @default.
- W71051318 cites W2033598785 @default.
- W71051318 cites W2128635872 @default.
- W71051318 cites W2134812217 @default.
- W71051318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8125720" @default.
- W71051318 hasPublicationYear "1994" @default.
- W71051318 type Work @default.
- W71051318 sameAs 71051318 @default.
- W71051318 citedByCount "93" @default.
- W71051318 countsByYear W710513182012 @default.
- W71051318 countsByYear W710513182013 @default.
- W71051318 countsByYear W710513182014 @default.
- W71051318 countsByYear W710513182015 @default.
- W71051318 countsByYear W710513182016 @default.
- W71051318 countsByYear W710513182017 @default.
- W71051318 countsByYear W710513182018 @default.
- W71051318 countsByYear W710513182019 @default.
- W71051318 countsByYear W710513182020 @default.
- W71051318 countsByYear W710513182021 @default.
- W71051318 countsByYear W710513182023 @default.
- W71051318 crossrefType "journal-article" @default.
- W71051318 hasAuthorship W71051318A5005016013 @default.
- W71051318 hasAuthorship W71051318A5041086406 @default.
- W71051318 hasAuthorship W71051318A5060911670 @default.
- W71051318 hasAuthorship W71051318A5069416813 @default.
- W71051318 hasAuthorship W71051318A5081413476 @default.
- W71051318 hasConcept C104317684 @default.
- W71051318 hasConcept C105580179 @default.
- W71051318 hasConcept C118487528 @default.
- W71051318 hasConcept C11988809 @default.
- W71051318 hasConcept C126322002 @default.
- W71051318 hasConcept C134018914 @default.
- W71051318 hasConcept C177707886 @default.
- W71051318 hasConcept C17991360 @default.
- W71051318 hasConcept C185592680 @default.
- W71051318 hasConcept C203014093 @default.
- W71051318 hasConcept C2776194053 @default.
- W71051318 hasConcept C2776415932 @default.
- W71051318 hasConcept C2778690821 @default.
- W71051318 hasConcept C2778754761 @default.
- W71051318 hasConcept C2780942790 @default.
- W71051318 hasConcept C2993390227 @default.
- W71051318 hasConcept C55493867 @default.
- W71051318 hasConcept C71924100 @default.
- W71051318 hasConcept C74172505 @default.
- W71051318 hasConceptScore W71051318C104317684 @default.
- W71051318 hasConceptScore W71051318C105580179 @default.
- W71051318 hasConceptScore W71051318C118487528 @default.
- W71051318 hasConceptScore W71051318C11988809 @default.
- W71051318 hasConceptScore W71051318C126322002 @default.
- W71051318 hasConceptScore W71051318C134018914 @default.
- W71051318 hasConceptScore W71051318C177707886 @default.
- W71051318 hasConceptScore W71051318C17991360 @default.
- W71051318 hasConceptScore W71051318C185592680 @default.
- W71051318 hasConceptScore W71051318C203014093 @default.
- W71051318 hasConceptScore W71051318C2776194053 @default.
- W71051318 hasConceptScore W71051318C2776415932 @default.
- W71051318 hasConceptScore W71051318C2778690821 @default.
- W71051318 hasConceptScore W71051318C2778754761 @default.
- W71051318 hasConceptScore W71051318C2780942790 @default.
- W71051318 hasConceptScore W71051318C2993390227 @default.
- W71051318 hasConceptScore W71051318C55493867 @default.
- W71051318 hasConceptScore W71051318C71924100 @default.
- W71051318 hasConceptScore W71051318C74172505 @default.
- W71051318 hasIssue "3" @default.
- W71051318 hasLocation W710513181 @default.
- W71051318 hasOpenAccess W71051318 @default.
- W71051318 hasPrimaryLocation W710513181 @default.
- W71051318 hasRelatedWork W1969385219 @default.
- W71051318 hasRelatedWork W1976031019 @default.
- W71051318 hasRelatedWork W2004741295 @default.
- W71051318 hasRelatedWork W2067874544 @default.
- W71051318 hasRelatedWork W2097636587 @default.
- W71051318 hasRelatedWork W2370781588 @default.
- W71051318 hasRelatedWork W2398267202 @default.
- W71051318 hasRelatedWork W3029663873 @default.
- W71051318 hasRelatedWork W59554962 @default.
- W71051318 hasRelatedWork W71051318 @default.
- W71051318 hasVolume "35" @default.
- W71051318 isParatext "false" @default.
- W71051318 isRetracted "false" @default.
- W71051318 magId "71051318" @default.
- W71051318 workType "article" @default.