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- W7107306 abstract "Human peripheral blood lymphocytes can express a low dose radiation induced adaptive response to subsequent radiation or chemical challenge. We are screening human T and B cell lines for differential expression of this phenomenon. Such lines should facilitate the identification of the factors underlying this phenomenon, and the conditions required to observe it. Our initial studies have used the T cell lines Molt-3 and CEM-CM3 and the B cell lines WIL2-NS and TK6. Two exposure scenarios were used: (1) a single exposure to 0.05 GY of x-rays followed 6 hrs. later 1 Gy, or (2) three 0.05 Gy exposures with 24 hr. intervals followed by 1 Gy 4 hrs after the last low dose exposure. To date we have triplicate experiments for each line. Under these conditions, TK6 is the only line to show an effect near significance (1 Gy CE 0.19{+-}0.04 vs 0.05{+-}1 Gy CE 0.24{+-}0.05, p=0.08, two tailed paired t-test) which was limited to scenario 1. Recently, Rigaud et al. reported on low dose radiation induced adaptive response to HGPRT mutation in the AHH-1 B cell line. We exposed cells of the WIL2-NS line to a single 0.05 Gy X-ray exposure followed by 6 hrs. later by 3more » Gy. To date we have performed 3 experiments. As with the above studies, there was no adaptive response for survival, however, there was a significant decrease in HGPRT mutation (73.2{+-}14.9 x 10{sup -6}for 3 Gy vs 45.8{+-}6.6 x 10{sup -6} for 0.05+3 Gy). These preliminary results suggest that the detection of low dose radiation induced adaptive responses will depend upon cell line, exposure conditions, and biological endpoint measured.« less" @default.
- W7107306 created "2016-06-24" @default.
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- W7107306 date "1994-12-31" @default.
- W7107306 modified "2023-09-26" @default.
- W7107306 title "Low dose radiation induced adaptive response in human T and B lymphocyte cell lines" @default.
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