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- W71140600 abstract "Abstract Isotretinoin, a pro-drug for retinoic acid, is the only agent that induces a permanent remission of acne, but the mechanism underlying its long-term efficacy is unknown. We hypothesized that modulation of the immune response to the bacterium involved in acne, P.acnes, is key to isotretinoin’s ability to induce long-term or permanent remissions of acne. This study is the first to investigate changes in peripheral immune cells associated with isotretinoin treatment in acne patients in vivo. Peripheral blood samples were obtained from acne patients before starting isotretinoin therapy (baseline) and at 1, 4, 8, and 20 weeks after starting isotretinoin therapy. Monocytes and lymphocytes were isolated, activated in vitro, and analyzed by flow cytometry. Acne patients’ monocytes expressed higher levels of TLR-2 and secreted more IL-1β, IL-6, IL-8, and IL-10 in response to P. acnes than monocytes from normal volunteers. Isotretinoin therapy significantly decreased TLR-2 expression on acne patients’ monocytes compared to their baselines, and this decrease was maintained at six months after the cessation of therapy. Additionally, isotretinoin therapy significantly decreased the secretion of IL-1β, IL-6, IL-8, and IL-10 by untreated and P.acnes-treated monocytes from acne patients compared to baseline. These results suggest that modulation of the immune response to P.acnes may represent one mechanism of isotretinoin’s long-term efficacy." @default.
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- W71140600 date "2011-04-01" @default.
- W71140600 modified "2023-09-25" @default.
- W71140600 title "Systemic isotretinoin treatment modulates patients’ immune response to <i>P. acnes</i> (111.23)" @default.
- W71140600 doi "https://doi.org/10.4049/jimmunol.186.supp.111.23" @default.
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