Matches in SemOpenAlex for { <https://semopenalex.org/work/W71231658> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W71231658 abstract "Histone deacetylase 7 (HDAC7) is a member of class IIa HDACs that regulate MEF2-mediated transcription and participate in multiple cellular processes. We have identified alpha actinin 1 and 4 as class IIa HDAC interacting proteins. The interaction domains are mapped to C-terminus of á actinin 4 and amino acids 72–172 of HDAC7. A point mutation in HDAC7 that disrupts its association with MEF2A also disrupts its association with á actinin 4, indicating that MEF2A and á actinin 4 binding sites are largely overlapping. We have also isolated a novel splice variant of á actinin 4 that is predominantly localized in the nucleus, a pattern distinct from the full-length á actinin 4, which is primarily distributed in the cytoplasm and plasma membrane. Using siRNA, ChIP, and transient transfection assays, we show that á actinin 4 potentiates expression of TAF55, a MEF2 target gene. Loss of MEF2A interaction correlates with loss of the ability of á actinin 4 to potentiate TAF55 promoter activity. Ectopic expression of á actinin 4, but not the mutant defective in MEF2A association, leads to disruption of HDAC7:MEF2A association and enhancement of MEF2-mediated transcription. Taken together, we have identified a novel mechanism by which HDAC7 activity is negatively regulated and uncovered a previously unknown function of á actinin 4." @default.
- W71231658 created "2016-06-24" @default.
- W71231658 creator A5003066423 @default.
- W71231658 creator A5027960395 @default.
- W71231658 creator A5031392337 @default.
- W71231658 creator A5037801778 @default.
- W71231658 creator A5045690971 @default.
- W71231658 creator A5059625696 @default.
- W71231658 creator A5060994810 @default.
- W71231658 creator A5085124229 @default.
- W71231658 date "2007-01-01" @default.
- W71231658 modified "2023-09-27" @default.
- W71231658 title "α Actinin 4 potentiates MEF2 transcription activity by antagonizing HDAC7" @default.
- W71231658 doi "https://doi.org/10.1096/fasebj.21.6.a1031" @default.
- W71231658 hasPublicationYear "2007" @default.
- W71231658 type Work @default.
- W71231658 sameAs 71231658 @default.
- W71231658 citedByCount "0" @default.
- W71231658 crossrefType "journal-article" @default.
- W71231658 hasAuthorship W71231658A5003066423 @default.
- W71231658 hasAuthorship W71231658A5027960395 @default.
- W71231658 hasAuthorship W71231658A5031392337 @default.
- W71231658 hasAuthorship W71231658A5037801778 @default.
- W71231658 hasAuthorship W71231658A5045690971 @default.
- W71231658 hasAuthorship W71231658A5059625696 @default.
- W71231658 hasAuthorship W71231658A5060994810 @default.
- W71231658 hasAuthorship W71231658A5085124229 @default.
- W71231658 hasConcept C104317684 @default.
- W71231658 hasConcept C111936080 @default.
- W71231658 hasConcept C133702464 @default.
- W71231658 hasConcept C138885662 @default.
- W71231658 hasConcept C142669718 @default.
- W71231658 hasConcept C143065580 @default.
- W71231658 hasConcept C1491633281 @default.
- W71231658 hasConcept C153911025 @default.
- W71231658 hasConcept C179926584 @default.
- W71231658 hasConcept C185592680 @default.
- W71231658 hasConcept C190062978 @default.
- W71231658 hasConcept C41895202 @default.
- W71231658 hasConcept C51183755 @default.
- W71231658 hasConcept C54355233 @default.
- W71231658 hasConcept C86339819 @default.
- W71231658 hasConcept C86803240 @default.
- W71231658 hasConcept C95444343 @default.
- W71231658 hasConcept C97037327 @default.
- W71231658 hasConceptScore W71231658C104317684 @default.
- W71231658 hasConceptScore W71231658C111936080 @default.
- W71231658 hasConceptScore W71231658C133702464 @default.
- W71231658 hasConceptScore W71231658C138885662 @default.
- W71231658 hasConceptScore W71231658C142669718 @default.
- W71231658 hasConceptScore W71231658C143065580 @default.
- W71231658 hasConceptScore W71231658C1491633281 @default.
- W71231658 hasConceptScore W71231658C153911025 @default.
- W71231658 hasConceptScore W71231658C179926584 @default.
- W71231658 hasConceptScore W71231658C185592680 @default.
- W71231658 hasConceptScore W71231658C190062978 @default.
- W71231658 hasConceptScore W71231658C41895202 @default.
- W71231658 hasConceptScore W71231658C51183755 @default.
- W71231658 hasConceptScore W71231658C54355233 @default.
- W71231658 hasConceptScore W71231658C86339819 @default.
- W71231658 hasConceptScore W71231658C86803240 @default.
- W71231658 hasConceptScore W71231658C95444343 @default.
- W71231658 hasConceptScore W71231658C97037327 @default.
- W71231658 hasIssue "6" @default.
- W71231658 hasLocation W712316581 @default.
- W71231658 hasOpenAccess W71231658 @default.
- W71231658 hasPrimaryLocation W712316581 @default.
- W71231658 hasRelatedWork W2017372504 @default.
- W71231658 hasRelatedWork W2033972109 @default.
- W71231658 hasRelatedWork W2034355620 @default.
- W71231658 hasRelatedWork W2038132520 @default.
- W71231658 hasRelatedWork W2041356725 @default.
- W71231658 hasRelatedWork W2098209017 @default.
- W71231658 hasRelatedWork W2100698867 @default.
- W71231658 hasRelatedWork W2139233441 @default.
- W71231658 hasRelatedWork W2499087690 @default.
- W71231658 hasRelatedWork W2946043455 @default.
- W71231658 hasVolume "21" @default.
- W71231658 isParatext "false" @default.
- W71231658 isRetracted "false" @default.
- W71231658 magId "71231658" @default.
- W71231658 workType "article" @default.