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- W71244318 abstract "This chapter discusses the immunosuppression and permanent transplantation tolerance across major histocompatibility barriers following total lymphoid irradiation. Bone marrow (BM) transplantation presents one of the most complicated problems in both clinical and experimental transplantation immunobiology. Successful allogeneic BM transplantation requires the establishment of initial engraftment, prevention of graft rejection, and avoiding or overcoming graft versus host disease (GVHD), which is a frequent lethal complication. A new approach to BM and transplantation across major histocompatibility barriers with induction of permanent and specific tolerance to donor-type alloantigens in different animal models using fractionated high dose total lymphoid irradiation has recently been developed. Two critical features of total lymphoid irradiation (TLI) used in animals and in man are the shielding of radiosensitive nonlymphoid organs with lead and the high dose of irradiation achieved by well-tolerable small daily fractions of 200 rads each." @default.
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- W71244318 date "1979-01-01" @default.
- W71244318 modified "2023-09-23" @default.
- W71244318 title "IMMUNOSUPPRESSION AND PERMANENT TRANSPLANTATION TOLERANCE ACROSS MAJOR HISTOCOMPATIBILITY BARRIERS FOLLOWING TOTAL LYMPHOID IRRADIATION" @default.
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- W71244318 doi "https://doi.org/10.1016/b978-0-12-569650-0.50118-2" @default.
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