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- W71285242 abstract "α-smooth muscle actin (α-SMA)-positive cardiac myofibroblasts (CMF) release paracrine mediators that affect cardiomyocyte (CM) structure and function. However, studies have used cardiac fibroblasts (CF) isolated from healthy hearts and activated to CMFs by culture. Whether freshly isolated SMA-negative CFs from healthy hearts affect CM structure and function and whether these effects are altered in CFs after pathological stimulation is unknown. We studied rat LV CFs freshly isolated from normal hearts (sham operated - S CF) and from hearts undergoing thoracic aortic constriction for 10 weeks (T CF). Within 24 hours of isolation CFs were cultured on Transwells above isolated adult rat LV myocytes to allow only paracrine communication (S CF+CM or T CF+CM). CMs co-cultured with other CMs were used as control (CM+CM). After 20 hours we measured adult CM size, contractility and Ca2+ handling. CM volume, assessed by Di-8-ANEPPS staining, was increased in S CF+CM and T CF+CM vs. CM+CM (µm3: CM+CM 40207±2171 (n=46), S CF+CM 47080±1895 (n=33), T CF+CM 48014±2049 (n=58); p" @default.
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- W71285242 date "2012-11-20" @default.
- W71285242 modified "2023-09-28" @default.
- W71285242 title "Abstract 10729: Freshly Isolated Fibroblasts From Normal Hearts Affect Cardiomyocyte Structure and Function Via Paracrine Communication, and These Effects are Altered in Fibroblasts From Pressure Overloaded Hearts" @default.
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