FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W71341605> ?p ?o ?g. }

• W71341605 endingPage "1053" @default.
• W71341605 startingPage "1048" @default.
• W71341605 abstract "Background Interferon-γ-inducible protein (IP)-10 (CXCL10) is an important chemokine secreted by the airway epithelium that functions as a biomarker for virus-induced asthma. Long-acting beta 2 (β 2 ) agonists (LABAs) are frequently used as inhaled medication for asthma and chronic obstructive pulmonary disease. However, previous research failed to investigate the effects of LABAs on IP-10 in bronchial epithelial cells. Objective To study the effects and signaling pathways of formoterol and salmeterol on polyriboinosinic polyribocytidylic acid (poly I:C)-induced IP-10 expression in BEAS-2B cells. Methods BEAS-2B cells were pretreated with formoterol and salmeterol for 2 hours before poly I:C stimulation. ICI 118551 (β 2 adrenoreceptor antagonist) or mitogen-activated protein kinase (MAPK) inhibitors were added 30 minutes before LABAs were added. Enzyme-linked immunosorbent assay and real-time polymerase chain reaction were used to measure IP-10 protein and messenger RNA levels. Mitogen-activated protein kinase inhibitors and Western blotting were used to identify MAPK pathways, whereas bioassay revealed the MAPK functions. Results Long-acting β 2 agonists significantly down-regulated the poly I:C-induced IP-10 protein and messenger RNA expression in BEAS-2B cells. ICI 118551 reversed this effect. Forskolin, a cyclic adenosine monophosphate activator, produced a similar inhibitory effect. Western blotting showed that formoterol suppressed poly I:C-induced IP-10 expression via the c-Jun N-terminal kinase–c-Jun pathway. Conclusion Long-acting β 2 agonists down-regulate poly I:C-induced IP-10 expression in BEAS-2B cells via the β 2 adrenoreceptor–cyclic adenosine monophosphate and c-Jun N-terminal kinase/c-Jun pathways. Long-acting β 2 agonists also inhibit IP-10 production in bronchial epithelial cells and may prolong viral elimination." @default.
• W71341605 created "2016-06-24" @default.
• W71341605 creator A5018999640 @default.
• W71341605 creator A5024588356 @default.
• W71341605 creator A5031672552 @default.
• W71341605 creator A5031745458 @default.
• W71341605 creator A5032331783 @default.
• W71341605 creator A5050900684 @default.
• W71341605 creator A5073269098 @default.
• W71341605 creator A5073595206 @default.
• W71341605 date "2012-10-01" @default.
• W71341605 modified "2023-09-30" @default.
• W71341605 title "Long-Acting Beta 2 Agonists Suppress IP-10 Expression in Human Bronchial Epithelial Cells" @default.
• W71341605 cites W1499666737 @default.
• W71341605 cites W1964779747 @default.
• W71341605 cites W1975670370 @default.
• W71341605 cites W1991648511 @default.
• W71341605 cites W1993787357 @default.
• W71341605 cites W1999011146 @default.
• W71341605 cites W2011781801 @default.
• W71341605 cites W2029030065 @default.
• W71341605 cites W2033336070 @default.
• W71341605 cites W2041595076 @default.
• W71341605 cites W2048053168 @default.
• W71341605 cites W2051088799 @default.
• W71341605 cites W2071223959 @default.
• W71341605 cites W2072937570 @default.
• W71341605 cites W2073463392 @default.
• W71341605 cites W2082354332 @default.
• W71341605 cites W2082731280 @default.
• W71341605 cites W2086958200 @default.
• W71341605 cites W2094580915 @default.
• W71341605 cites W2094688070 @default.
• W71341605 cites W2100158520 @default.
• W71341605 cites W2107838877 @default.
• W71341605 cites W2112692443 @default.
• W71341605 cites W2126675070 @default.
• W71341605 cites W2129071472 @default.
• W71341605 cites W2137919479 @default.
• W71341605 cites W2144674546 @default.
• W71341605 cites W2151041131 @default.
• W71341605 cites W2167713965 @default.
• W71341605 doi "https://doi.org/10.2310/jim.0b013e3182673ff9" @default.
• W71341605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22914602" @default.
• W71341605 hasPublicationYear "2012" @default.
• W71341605 type Work @default.
• W71341605 sameAs 71341605 @default.
• W71341605 citedByCount "7" @default.
• W71341605 countsByYear W713416052015 @default.
• W71341605 countsByYear W713416052016 @default.
• W71341605 countsByYear W713416052017 @default.
• W71341605 countsByYear W713416052018 @default.
• W71341605 countsByYear W713416052022 @default.
• W71341605 crossrefType "journal-article" @default.
• W71341605 hasAuthorship W71341605A5018999640 @default.
• W71341605 hasAuthorship W71341605A5024588356 @default.
• W71341605 hasAuthorship W71341605A5031672552 @default.
• W71341605 hasAuthorship W71341605A5031745458 @default.
• W71341605 hasAuthorship W71341605A5032331783 @default.
• W71341605 hasAuthorship W71341605A5050900684 @default.
• W71341605 hasAuthorship W71341605A5073269098 @default.
• W71341605 hasAuthorship W71341605A5073595206 @default.
• W71341605 hasConcept C126322002 @default.
• W71341605 hasConcept C13373296 @default.
• W71341605 hasConcept C153911025 @default.
• W71341605 hasConcept C170493617 @default.
• W71341605 hasConcept C184235292 @default.
• W71341605 hasConcept C185592680 @default.
• W71341605 hasConcept C189165786 @default.
• W71341605 hasConcept C2776042228 @default.
• W71341605 hasConcept C2776136866 @default.
• W71341605 hasConcept C2776668983 @default.
• W71341605 hasConcept C2776719499 @default.
• W71341605 hasConcept C2777699602 @default.
• W71341605 hasConcept C2779276759 @default.
• W71341605 hasConcept C2779871671 @default.
• W71341605 hasConcept C55493867 @default.
• W71341605 hasConcept C57074206 @default.
• W71341605 hasConcept C5858377 @default.
• W71341605 hasConcept C62478195 @default.
• W71341605 hasConcept C71924100 @default.
• W71341605 hasConcept C86803240 @default.
• W71341605 hasConcept C88045685 @default.
• W71341605 hasConcept C97029542 @default.
• W71341605 hasConcept C98274493 @default.
• W71341605 hasConceptScore W71341605C126322002 @default.
• W71341605 hasConceptScore W71341605C13373296 @default.
• W71341605 hasConceptScore W71341605C153911025 @default.
• W71341605 hasConceptScore W71341605C170493617 @default.
• W71341605 hasConceptScore W71341605C184235292 @default.
• W71341605 hasConceptScore W71341605C185592680 @default.
• W71341605 hasConceptScore W71341605C189165786 @default.
• W71341605 hasConceptScore W71341605C2776042228 @default.
• W71341605 hasConceptScore W71341605C2776136866 @default.
• W71341605 hasConceptScore W71341605C2776668983 @default.
• W71341605 hasConceptScore W71341605C2776719499 @default.
• W71341605 hasConceptScore W71341605C2777699602 @default.
• W71341605 hasConceptScore W71341605C2779276759 @default.

• next