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• W714337 abstract "Research Article1 June 1988free access Comparison of the in vitro transforming activities of human papillomavirus types. A. Storey A. Storey Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author D. Pim D. Pim Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author A. Murray A. Murray Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author K. Osborn K. Osborn Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author L. Banks L. Banks Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author L. Crawford L. Crawford Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author A. Storey A. Storey Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author D. Pim D. Pim Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author A. Murray A. Murray Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author K. Osborn K. Osborn Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author L. Banks L. Banks Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author L. Crawford L. Crawford Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author Author Information A. Storey1, D. Pim1, A. Murray1, K. Osborn1, L. Banks1 and L. Crawford1 1Molecular Virology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. The EMBO Journal (1988)7:1815-1820https://doi.org/10.1002/j.1460-2075.1988.tb03013.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The association of certain human papillomavirus (HPV) types with the majority of human cervical carcinomas suggests a role for the virus in the development of this type of cancer. In this paper, we have examined the transforming properties of several HPV types where the early region genes of the virus are under the control of a strong heterologous promoter and show that major differences exist between the HPV types in their ability to transform primary rat kidney epithelial cells in conjunction with an activated ras oncogene. Those HPV types most commonly found in carcinomas–types 16, 18, 31 and 33–are capable of co-operating with ras to transform primary cells, but those types most commonly found in benign lesions–types 6 and 11–are not. We further demonstrate that the E7 gene of HPV16 by itself is sufficient to co-operate with activated ras to produce transformed cells which are tumorigenic in immunocompetent animals. Previous ArticleNext Article Volume 7Issue 61 June 1988In this issue RelatedDetailsLoading ..." @default.
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• W714337 title "Comparison of the in vitro transforming activities of human papillomavirus types." @default.
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